INT24581

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Context Info
Confidence 0.40
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.05
Pain Relevance 0.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (LTC4S) nuclear envelope (LTC4S) small molecule metabolic process (LTC4S)
lyase activity (LTC4S) endoplasmic reticulum (LTC4S) nucleus (LTC4S)
LTC4S (Homo sapiens)
Pain Link Frequency Relevance Heat
Cluster headache 8 99.20 Very High Very High Very High
Inflammation 14 84.72 Quite High
substance P 1 81.52 Quite High
bradykinin 1 80.24 Quite High
Onset of action 13 57.80 Quite High
cytokine 2 29.12 Quite Low
Inflammatory response 1 17.44 Low Low
Antihistamine 23 5.00 Very Low Very Low Very Low
corticosteroid 14 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cluster Headache 8 99.20 Very High Very High Very High
Rhinitis 101 95.60 Very High Very High Very High
Edema 2 93.76 High High
Hypersensitivity 22 92.52 High High
INFLAMMATION 15 84.72 Quite High
Congenital Anomalies 1 70.00 Quite High
Pruritus 5 60.72 Quite High
Sneezing 9 59.76 Quite High
Cancer 1 47.92 Quite Low
Necrosis 1 47.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A reduction of LTC4 and LTB4 levels in CH patients was also observed in R-P HPLC, which showed different elution patterns in the two groups.
Negative_regulation (reduction) of LTC4 associated with cluster headache
1) Confidence 0.40 Published 1989 Journal Headache Section Abstract Doc Link 2466813 Disease Relevance 0.72 Pain Relevance 0.65
It does this possibly by reducing the production of leukotriene (LT)B4 synthase and LTC4, inhibiting phospholipase A2 and LTC4 (Hamasaki et al 1996).
Negative_regulation (inhibiting) of LTC4
2) Confidence 0.18 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621402 Disease Relevance 1.33 Pain Relevance 0.25

General Comments

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