INT245826

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Context Info
Confidence 0.09
First Reported 2007
Last Reported 2007
Negated 0
Speculated 1
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.57
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Plg, Serpinf1) extracellular region (Plg, Serpinf1) peptidase activity (Plg)
aging (Serpinf1) cellular_component (Serpinf1)
Anatomy Link Frequency
retina 2
Plg (Mus musculus)
Serpinf1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 3 71.52 Quite High
cINOD 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 6 98.08 Very High Very High Very High
Injury 3 97.48 Very High Very High Very High
Diabetes Mellitus 216 91.12 High High
Diabetic Retinopathy 3 74.48 Quite High
Retinal Neovascularization 3 72.92 Quite High
Cv Unclassified Under Development 3 71.52 Quite High
Diabetic Macular Edema 33 40.16 Quite Low
Increased Venous Pressure Under Development 3 29.20 Quite Low
Age-related Macular Degeneration 18 19.68 Low Low
Hypoxia 6 12.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further research is warranted to explore the effect of rAAV-angiostatin on PEDF expression.
angiostatin Regulation (effect) of Gene_expression (expression) of PEDF
1) Confidence 0.09 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.82 Pain Relevance 0.04
Effects of rAAV-angiostatin on expression of vascular endothelial growth factor (VEGF), pigment epithelium-derived factor (PEDF), occludin, and phospho-p42/p44 MAP kinase in retina tissue were analyzed by western blotting.


angiostatin Spec (analyzed) Regulation (Effects) of Spec (analyzed) Gene_expression (expression) of PEDF in retina
2) Confidence 0.08 Published 2007 Journal Molecular Vision Section Abstract Doc Link PMC2533034 Disease Relevance 0.38 Pain Relevance 0
To further evaluate if rAAV-angiostatin could influence PEDF expression, we infected HUVEC-2C cells with rAAV-angiostatin.
angiostatin Regulation (influence) of Gene_expression (expression) of PEDF
3) Confidence 0.07 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.36 Pain Relevance 0

General Comments

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