INT245832

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.61
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (VEGFA, Ocln) cytosol (Ocln) extracellular space (VEGFA)
growth (VEGFA) extracellular region (VEGFA) proteinaceous extracellular matrix (VEGFA)
VEGFA (Homo sapiens)
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 2 48.72 Quite Low
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 144 99.72 Very High Very High Very High
Targeted Disruption 4 87.44 High High
Increased Venous Pressure Under Development 2 86.12 High High
Diabetic Macular Edema 22 84.68 Quite High
Apoptosis 4 72.84 Quite High
Metastasis 2 69.80 Quite High
Hypoxia 4 69.40 Quite High
Cancer 2 68.92 Quite High
Ocular Toxicity (including Many Sub-types) 4 60.44 Quite High
Age-related Macular Degeneration 12 55.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
VEGF stimulates phosphorylation and redistribution of occludin [19], which is subsequently endocytosed and degraded [47,48].
VEGF Positive_regulation (stimulates) of Phosphorylation (phosphorylation) of occludin
1) Confidence 0.04 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.78 Pain Relevance 0
Furthermore, VEGF affects the tight junction protein occludin, inducing occludin phosphorylation [19] and redistribution [20]; resultant occludin reduction is associated with BRB breakdown in diabetes [21].
VEGF Positive_regulation (inducing) of Phosphorylation (phosphorylation) of occludin associated with diabetes mellitus
2) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.83 Pain Relevance 0

General Comments

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