INT245833

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.21
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Plg, VEGFA) extracellular region (Plg, VEGFA) peptidase activity (Plg)
growth (VEGFA) proteinaceous extracellular matrix (VEGFA) cytoplasm (VEGFA)
Anatomy Link Frequency
endothelial cells 1
Plg (Mus musculus)
VEGFA (Homo sapiens)
Pain Link Frequency Relevance Heat
ischemia 2 78.24 Quite High
cINOD 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 100.00 Very High Very High Very High
Metastasis 2 99.60 Very High Very High Very High
Cancer 2 98.72 Very High Very High Very High
Diabetes Mellitus 144 96.20 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 4 90.24 High High
Age-related Macular Degeneration 12 85.00 Quite High
Cv Unclassified Under Development 2 78.24 Quite High
Retinal Neovascularization 2 76.88 Quite High
Diabetic Retinopathy 2 74.40 Quite High
Increased Venous Pressure Under Development 2 70.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Angiostatin specifically inhibits proliferation, induces apoptosis in vascular endothelial cells [12], and downregulates vascular endothelial growth factor (VEGF), the latter via inactivation of the p42/p44 MAP kinase pathway [9,13,14].
Angiostatin Negative_regulation (downregulates) of VEGF in endothelial cells associated with apoptosis
1) Confidence 0.05 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 1.30 Pain Relevance 0
The rAAV-angiostatin-induced inhibition of VEGF may therefore suppress vascular leakage by preserving retinal occludin content in STZ-induced diabetic rats
angiostatin Negative_regulation (inhibition) of VEGF associated with diabetes mellitus
2) Confidence 0.03 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0.91 Pain Relevance 0.04

General Comments

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