INT24584

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Context Info
Confidence 0.44
First Reported 1982
Last Reported 2004
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 0.07
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (MTR) small molecule metabolic process (MTR) methyltransferase activity (MTR)
intracellular (MTR) cellular nitrogen compound metabolic process (MTR) cytoplasm (MTR)
Anatomy Link Frequency
B12 1
MTR (Homo sapiens)
Pain Link Frequency Relevance Heat
Enkephalin 5 100.00 Very High Very High Very High
anesthesia 5 97.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Spinal Cord Diseases 2 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Inactivation of methionine synthetase progressively increased as the product of the concentration of nitrous oxide and the exposure time increased.
Positive_regulation (Inactivation) of methionine synthetase
1) Confidence 0.44 Published 1982 Journal Anesth. Analg. Section Abstract Doc Link 7198880 Disease Relevance 0 Pain Relevance 0
These results in humans are similar to those in animals and suggest that inactivation of methionine synthetase may play a role in the development of the pathologic effects seen in patients and medical personnel after exposure to nitrous oxide.
Positive_regulation (inactivation) of methionine synthetase
2) Confidence 0.44 Published 1982 Journal Anesth. Analg. Section Abstract Doc Link 7198880 Disease Relevance 0 Pain Relevance 0
The stability of methionine enkephalin (M-E) during long term storage was investigated using various anticoagulants and enzyme inhibitors, eg EDTA, heparin, trasylol, citric acid.
Spec (investigated) Positive_regulation (stability) of methionine enkephalin associated with enkephalin
3) Confidence 0.43 Published 1989 Journal Life Sci. Section Abstract Doc Link 2467157 Disease Relevance 0 Pain Relevance 0.42
Inactivation of methionine synthase is very much more rapid in the rat exposed to 50% nitrous oxide, with a half-time of 5.4 min.
Positive_regulation (Inactivation) of methionine synthase
4) Confidence 0.23 Published 1988 Journal Anesthesiology Section Abstract Doc Link 3341574 Disease Relevance 0 Pain Relevance 0.19
By inactivating cobalamin (Cbl) (vitamin B12), N2O can cause neurologic and hematologic manifestations.
Positive_regulation (inactivating) of cobalamin in B12
5) Confidence 0.05 Published 2004 Journal J Neuroimaging Section Abstract Doc Link 15228771 Disease Relevance 0.07 Pain Relevance 0.09

General Comments

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