INT245844

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Context Info
Confidence 0.58
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 26
Disease Relevance 24.82
Pain Relevance 1.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
taste bud 6
taste receptor cells 2
reservoir 2
liver 1
ganglia 1
Tir1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 11 99.92 Very High Very High Very High
opiate 11 97.68 Very High Very High Very High
Calcium channel 22 95.84 Very High Very High Very High
medulla 154 86.84 High High
parabrachial 33 70.68 Quite High
palliative 15 60.44 Quite High
Pain 11 20.88 Low Low
trigeminal ganglion 66 5.00 Very Low Very Low Very Low
fifth nerve 22 5.00 Very Low Very Low Very Low
Central nervous system 11 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatitis B Virus Infection 720 100.00 Very High Very High Very High
Infection 450 100.00 Very High Very High Very High
Liver Disease 75 99.48 Very High Very High Very High
Chronic Hepatitis 75 99.28 Very High Very High Very High
Death 30 99.16 Very High Very High Very High
Targeted Disruption 231 99.10 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 135 98.92 Very High Very High Very High
Hepatocellular Cancer 120 98.60 Very High Very High Very High
Hepatitis C Virus Infection 15 97.36 Very High Very High Very High
Immunodeficiency 15 97.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The discovery that T1r1, T1r2 and T2rs do not co-express in the taste bud [8] suggests that subsets of cells expressing T1r1, T1r2, and T2rs may constitute the origin of a labeled line for umami, sweet and bitter, respectively.
Gene_expression (co-express) of T1r in taste bud
1) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.24 Pain Relevance 0.10
The discovery that T1r1, T1r2 and T2rs do not co-express in the taste bud [8] suggests that subsets of cells expressing T1r1, T1r2, and T2rs may constitute the origin of a labeled line for umami, sweet and bitter, respectively.
Gene_expression (expressing) of T1r in taste bud
2) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.26 Pain Relevance 0.11
2 knockout mice restores bitter but not sweet or umami tastes [9], and transgenic expression of a modified opioid receptor in T1r2-expressing taste receptor cells leads to preference for a synthetic opiate [10].
Gene_expression (expressing) of T1r in taste receptor cells associated with targeted disruption, opiate and opioid receptor
3) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.29 Pain Relevance 0.15
Our data show that WGA originally expressed in T1r3-expressing type II taste receptor cells is transported to the geniculate and petrosal ganglia, and not to neighboring taste cells.
Gene_expression (expressing) of T1r in ganglia
4) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.15 Pain Relevance 0.10
The discovery that T1r1, T1r2 and T2rs do not co-express in the taste bud [8] suggests that subsets of cells expressing T1r1, T1r2, and T2rs may constitute the origin of a labeled line for umami, sweet and bitter, respectively.
Gene_expression (co-express) of T1r1 in taste bud
5) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.24 Pain Relevance 0.10
BM carried out the immunohistochemical study of co-expression of T1r3 and WGA, RFM contributed to the design of the study and revised the manuscript.
Gene_expression (co-expression) of T1r
6) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.08 Pain Relevance 0
The discovery that T1r1, T1r2 and T2rs do not co-express in the taste bud [8] suggests that subsets of cells expressing T1r1, T1r2, and T2rs may constitute the origin of a labeled line for umami, sweet and bitter, respectively.
Gene_expression (expressing) of T1r1 in taste bud
7) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.26 Pain Relevance 0.11
The discovery that T1r1, T1r2 and T2rs do not co-express in the taste bud [8] suggests that subsets of cells expressing T1r1, T1r2, and T2rs may constitute the origin of a labeled line for umami, sweet and bitter, respectively.
Gene_expression (co-express) of T1r in taste bud
8) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.24 Pain Relevance 0.10
T1r3-expressing taste cells are type II cells which do not express the presynaptic molecules SNAP-25 and voltage-gated calcium channels required for synaptic transmission [16].
Gene_expression (expressing) of T1r associated with calcium channel
9) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.08 Pain Relevance 0.10
The discovery that T1r1, T1r2 and T2rs do not co-express in the taste bud [8] suggests that subsets of cells expressing T1r1, T1r2, and T2rs may constitute the origin of a labeled line for umami, sweet and bitter, respectively.
Gene_expression (expressing) of T1r in taste bud
10) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.26 Pain Relevance 0.11
Immunohistochemistry with a T1r3 antibody showed co-expression of GFP and T1r3 in a subset of taste receptor cells, demonstrating that the WGA-IRES-GFP transgene was correctly expressed in the cells that normally express T1r3 (Figure 1a for co-expression in the CV, not shown for foliate and fungiform papillae).
Gene_expression (co-expression) of T1r in taste receptor cells
11) Confidence 0.58 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2571104 Disease Relevance 0.17 Pain Relevance 0.07
chronic HBV infection and preserving the reservoir of chronic hepatitis B
Gene_expression (preserving) of infection in reservoir associated with chronic hepatitis, hepatitis b virus infection and infection
12) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 1.95 Pain Relevance 0
intervention, in order to limit the spread of the infection and to further
Gene_expression (spread) of infection associated with infection
13) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 0.51 Pain Relevance 0
chronic HBV infection and preserving the reservoir of chronic hepatitis B
Gene_expression (chronic) of infection in reservoir associated with chronic hepatitis, hepatitis b virus infection and infection
14) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 1.95 Pain Relevance 0
high in hyperendemic regions of HBV infection (10–150 cases/100.000 people per year) compared to regions of lower
Gene_expression (regions) of infection associated with hepatitis b virus infection and infection
15) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 1.96 Pain Relevance 0
The widespread of HBV infection in the
Gene_expression (widespread) of infection associated with hepatitis b virus infection and infection
16) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 1.22 Pain Relevance 0
common ways of HBV infection dispersion, mainly in hyperendemic areas of the
Gene_expression (dispersion) of infection associated with hepatitis b virus infection and infection
17) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 1.11 Pain Relevance 0
The prevalence of the infection varies
Gene_expression (prevalence) of infection associated with infection
18) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 1.77 Pain Relevance 0
Likewise, significant differences of the prevalence of HBV infection are
Gene_expression (prevalence) of infection associated with hepatitis b virus infection and infection
19) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 1.18 Pain Relevance 0
Central and Eastern Europe as well as those of the Mediterranean basin, the Amazon’s sink, Middle East, and Northern
Africa are regions of medium HBV infection
Gene_expression (regions) of infection associated with hepatitis b virus infection and infection
20) Confidence 0.50 Published 2008 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2533103 Disease Relevance 1.88 Pain Relevance 0

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