INT245853

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Context Info
Confidence 0.07
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 0.20
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Erc1) Golgi apparatus (Erc1) cytoplasm (Erc1)
Erc1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 47 50.00 Quite Low
cytokine 8 25.04 Quite Low
imagery 19 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain score 1 5.00 Very Low Very Low Very Low
Arthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 21 70.52 Quite High
Amyloid Plaque 3 68.88 Quite High
Cv Unclassified Under Development 46 50.00 Quite Low
Infection 24 49.68 Quite Low
Scrapie 39 34.36 Quite Low
Creutzfeldt Jakob Disease 24 5.00 Very Low Very Low Very Low
Sprains And Strains 18 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Pain 7 5.00 Very Low Very Low Very Low
Coronary Artery Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indeed, by inhibiting PrP exit from the ERC using the Rab11 dominant-negative mutant, we found an increase in PrPSc levels, supporting the hypothesis that prion accumulation in the ERC stimulates PrPSc production.
Positive_regulation (accumulation) of ERC
1) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.20 Pain Relevance 0
Angiogenic potential of ERC
Positive_regulation (potential) of ERC
2) Confidence 0.06 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0 Pain Relevance 0
However, in contrast to control cells, Tfn was not transported to the ERC after internalization, but remained inside EEs (?
Positive_regulation (transported) of ERC
3) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
Overall these data strongly suggest that PrPSc conversion occurs in the ERC and imply that recycling from ERC to the PM is not relevant to this process.


Positive_regulation (occurs) of ERC
4) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0

General Comments

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