INT245857

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Context Info
Confidence 0.10
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.52
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Erc1) Golgi apparatus (Erc1) cytoplasm (Erc1)
Anatomy Link Frequency
HeLa 2
Erc1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 47 50.00 Quite Low
Arthritis 1 35.84 Quite Low
imagery 25 5.00 Very Low Very Low Very Low
cytokine 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
Central nervous system 4 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain score 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Scrapie 52 89.04 High High
Coronary Artery Disease 9 85.88 High High
Skin Cancer 1 62.16 Quite High
Cancer 6 59.68 Quite High
Graft Vs Host Disease 1 59.68 Quite High
Disease 27 50.48 Quite High
Cv Unclassified Under Development 46 50.00 Quite Low
Wound Healing 2 39.96 Quite Low
Experimental Autoimmune Encephalomyelitis 1 37.80 Quite Low
Experimental Arthritis 1 35.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Clinical entry of ERC
Localization (entry) of ERC
1) Confidence 0.10 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.23 Pain Relevance 0
In contrast to CHO cells, when GFP-Rab22a is overexpressed in HeLa cells it localized to the ERC and to tubular carriers and does not affect either the distribution or the recycling of Tfn [42].
Localization (localized) of ERC in HeLa
2) Confidence 0.08 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.11 Pain Relevance 0
Interestingly, compared to control cells, a higher amount of PrPSc was observed to colocalize with Tfn in the ERC of transfected cells (Figure 7A lower panels) indicating that PrP was also retained in this compartment.
Localization (colocalize) of ERC
3) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
In contrast, in ScN2a cells, Rab22a behaved similarly to HeLa cells and did not inhibit the trafficking of Tfn from EEs to the ERC.
Localization (trafficking) of ERC in HeLa
4) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.09 Pain Relevance 0
Since endogenous PrPC accumulates in EEs in the presence of U18666A (Figures 2C and 2D), overall these results indicate that EEs (and recycling from EEs to the PM) are not involved in PrPSc production, while exit of PrP from EEs towards either the ERC or LEs is required for conversion to occur.
Localization (exit) of ERC
5) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.09 Pain Relevance 0

General Comments

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