INT245859

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Context Info
Confidence 0.05
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.85
Pain Relevance 0.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Epc1) nucleus (Epc1)
Anatomy Link Frequency
blood 1
corpus 1
skin 1
Epc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 58 97.92 Very High Very High Very High
fibrosis 4 97.04 Very High Very High Very High
ischemia 47 79.08 Quite High
cytokine 12 26.96 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Buprenorphine 2 5.00 Very Low Very Low Very Low
chemokine 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Injury 232 99.56 Very High Very High Very High
INFLAMMATION 65 97.92 Very High Very High Very High
Fibrosis 4 97.04 Very High Very High Very High
Wound Healing 24 96.16 Very High Very High Very High
Cancer 6 94.88 High High
Cytomegalovirus Infection 28 93.32 High High
Cv Unclassified Under Development 46 79.08 Quite High
Obesity 2 75.76 Quite High
Diabetes Mellitus 79 47.64 Quite Low
Adhesions 6 8.48 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test whether the differences in EPCs present in HOXA3-treated wounds at day 7 were due to enhanced EPC recruitment, and/or could be attributed to increased mobilization of EPCs from the bone marrow, we analyzed blood samples collected both from db/db mice treated with CMV-HOXA3 or control plasmid, as well as db/+ mice treated with control plasmid.
Positive_regulation (enhanced) of EPC in blood associated with injury and cytomegalovirus infection
1) Confidence 0.05 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.67 Pain Relevance 0
Although application of this factor has been linked to improved repair and increased EPC recruitment, Ccl2-null mice also displayed reduced inflammation and skin fibrosis after wounding [56].
Positive_regulation (increased) of EPC in skin associated with fibrosis and inflammation
2) Confidence 0.04 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2733377 Disease Relevance 0.57 Pain Relevance 0.14
EPC derived from the genetically marked bone marrow were shown to promote physiological (corpus luteal and wound healing), and pathogenic (cancer) angiogenesis.
Positive_regulation (derived) of EPC in corpus associated with cancer and wound healing
3) Confidence 0.01 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.61 Pain Relevance 0.21

General Comments

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