INT245861

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Context Info
Confidence 0.65
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 1.18
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Erc1) Golgi apparatus (Erc1) cytoplasm (Erc1)
Anatomy Link Frequency
cholinergic neurons 1
stromal cells 1
lymphocyte 1
stem cells 1
Erc1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 141 72.48 Quite High
Arthritis 3 58.96 Quite High
anesthesia 6 57.64 Quite High
cytokine 24 52.08 Quite High
imagery 23 5.00 Very Low Very Low Very Low
Pain 19 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pain score 3 5.00 Very Low Very Low Very Low
cva 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Infection 108 97.88 Very High Very High Very High
Neuroblastoma 3 84.16 Quite High
Disease 30 84.00 Quite High
Graft Vs Host Disease 3 82.80 Quite High
Amyloid Plaque 3 82.36 Quite High
Cv Unclassified Under Development 138 72.48 Quite High
Wound Healing 6 63.08 Quite High
Experimental Autoimmune Encephalomyelitis 3 60.92 Quite High
Scrapie 39 59.84 Quite High
Experimental Arthritis 3 58.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These human genes include early endosome antigen 1 (EEA1; 72%), Rab6 interacting protein 2 (ELKS; 63%) and ATPase (ATP6V0A1; 77%).
Gene_expression (include) of ELKS
1) Confidence 0.65 Published 2010 Journal Virol J Section Body Doc Link PMC2825209 Disease Relevance 0.21 Pain Relevance 0
In preliminary experiments we have demonstrated that addition of ERC to ongoing mixed lymphocyte reactions results in suppression of proliferation (Figure 3a), inhibition of IFN-gamma (Figure 3b), stimulation of IL-4 (figure 3c) and inhibition of TNF-alpha after LPS stimulation (Figure 3d).
Gene_expression (addition) of ERC in lymphocyte
2) Confidence 0.09 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0.47 Pain Relevance 0.07
We believe the ERC represents a unique population of cells in contrast to endometrial stromal cells based on: a) different rate of proliferation (ERC proliferate approximately once every 19 hours, whereas stromal cells every 24–36 hours); b) ability to differentiate into a wide number of tissues, stromal cells have only been shown to differentiate into bone, fat, and cartilage; c) ERC lack expression of STRO-1, whereas other stromal derived cells express this marker.
Gene_expression (expression) of ERC in stromal cells
3) Confidence 0.08 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0 Pain Relevance 0
Some degree of similarity exists between ERC and bone marrow derived mesenchymal stem cells, for example, expression of CD90, CD105 and lack of CD45 and CD34 [57].
Gene_expression (expression) of ERC in stem cells
4) Confidence 0.08 Published 2008 Journal J Transl Med Section Body Doc Link PMC2533293 Disease Relevance 0 Pain Relevance 0.03
In addition to this well documented effect, we found that in U18666A treated cells fluorescently tagged Tfn was not able to reach the ERC and after 15 minutes of internalization was still arrested in EEs both in ScGT1 (Figure 3B) and ScN2a cells (Figure S3D).
Gene_expression (able) of ERC
5) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0 Pain Relevance 0
In this scenario PrP retention in the ERC might be necessary in order to concentrate prion proteins in a cholesterol enriched membrane domain for a sufficient amount of time to promote conversion.
Gene_expression (retention) of ERC
6) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.36 Pain Relevance 0
Furthermore, a chimeric protein fused with GFP (GFP-PrPC) expressed in SN56 cells derived from septal cholinergic neurons, has been detected in the Golgi, early endosomes (EEs), and in the endosomal recycling compartment (ERC) [14].
Gene_expression (detected) of ERC in cholinergic neurons
7) Confidence 0.06 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2673690 Disease Relevance 0.14 Pain Relevance 0.06

General Comments

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