INT245896

Context Info Confidence 0.47 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.35 Pain Relevance 0.09

Anatomy Link Frequency hippocampus 2 Hcn4 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Hippocampus 4 98.16 HCN1 64 46.48 hCN2 8 44.12 sodium channel 8 41.28 potassium channel 6 5.00 Calcium channel 6 5.00 adenocard 4 5.00 Spinal cord 2 5.00 member 8 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Aging 44 98.84 Ganglion Cysts 4 5.00 Overdose 2 5.00 Lifespan 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

There is a linear decrease in the expression of HCN4 throughout the reproductive aging process in the female rat.

Negative_regulation (decrease) of Gene_expression (expression) of HCN4 associated with aging

1) Confidence 0.47 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.72 Pain Relevance 0.04

Brewster et al. and Surges et al. showed a steady decrease in HCN4 expression throughout the maturation process of the rat hippocampus [23,24].

Negative_regulation (decrease) of Gene_expression (expression) of HCN4 in hippocampus associated with hippocampus

2) Confidence 0.47 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.63 Pain Relevance 0.05

General Comments

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