INT245898

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 1.84
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
heart 4
oocytes 1
Hcn4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 32 98.76 Very High Very High Very High
Action potential 204 84.96 Quite High
Nav1.1 7 77.64 Quite High
Hippocampus 2 59.32 Quite High
member 8 1 35.68 Quite Low
Calcium channel 3 23.44 Low Low
adenocard 2 6.56 Low Low
metalloproteinase 28 5.00 Very Low Very Low Very Low
fibrosis 14 5.00 Very Low Very Low Very Low
action potential duration 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 99 99.78 Very High Very High Very High
Heart Rate Under Development 63 93.24 High High
Targeted Disruption 7 87.00 High High
Body Weight 7 70.16 Quite High
Obesity 21 50.00 Quite Low
Hypertrophy 42 40.40 Quite Low
Fibrosis 35 5.00 Very Low Very Low Very Low
Necrosis 7 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Disease 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To test these possibilities, the effect of blockade of Nav1.5 and HCN4 on the spontaneous activity of right atrial preparations was investigated—if the age-dependent decrease in the intrinsic heart rate is the result of a decline in either INa or If, blockade of the corresponding ion channel should have a smaller effect on the heart rate in the older animal.
Negative_regulation (blockade) of HCN4 in heart
1) Confidence 0.40 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.17 Pain Relevance 0.07
There are decreases in the expression of HCN1, 3, and 4 in the oocytes during reproductive aging, with the decrease in HCN4 being the most pronounced.
Negative_regulation (decrease) of HCN4 in oocytes associated with aging and hcn1
2) Confidence 0.35 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.31 Pain Relevance 0.17
In summary, there is an age-dependent increase rather than decrease in the sensitivity of the pacemaker activity of the SAN to blockade of Nav1.5 and HCN4, and therefore, it is unlikely that the age-dependent decrease in the intrinsic heart rate is the result of a decline in INa or If.


Negative_regulation (blockade) of HCN4 in heart
3) Confidence 0.29 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0 Pain Relevance 0.04
Age-dependent increase in sensitivity to blockade of Nav1.5 and HCN4
Negative_regulation (blockade) of HCN4
4) Confidence 0.29 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.21 Pain Relevance 0.03
If the decrease in the intrinsic heart rate during ageing is the result of another factor (e.g. decrease of L-type Ca2+ current [28] or ‘Ca2+ clock [31]), blockade of Nav1.5 and HCN4 may result in a larger effect in the old animal.
Negative_regulation (blockade) of HCN4 in heart associated with aging
5) Confidence 0.29 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.38 Pain Relevance 0.03
The greater sensitivity of SAN pacemaking in old animals to blockade of Nav1.5 and HCN4 possibly results from a shift in the relative contribution of different ionic mechanisms to pacemaking.
Negative_regulation (blockade) of HCN4
6) Confidence 0.29 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.38 Pain Relevance 0.04
Blockade of HCN4 also had a greater effect on the heart rate in the old animal (Fig. 1).
Negative_regulation (Blockade) of HCN4 in heart
7) Confidence 0.29 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.33 Pain Relevance 0.04
HCN4 was blocked by the application of 2 mM Cs+ or 10 ?
Negative_regulation (blocked) of HCN4
8) Confidence 0.29 Published 2010 Journal Journal of Molecular and Cellular Cardiology Section Body Doc Link PMC2845824 Disease Relevance 0.06 Pain Relevance 0.08

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox