INT245899

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.89
Pain Relevance 0.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Hcn3)
Anatomy Link Frequency
granulosa cells 5
oocytes 1
Hcn3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
HCN1 96 95.76 Very High Very High Very High
hCN2 12 72.36 Quite High
sodium channel 12 69.52 Quite High
Hippocampus 6 57.56 Quite High
member 8 3 40.64 Quite Low
Calcium channel 9 28.40 Quite Low
potassium channel 9 12.84 Low Low
adenocard 6 11.52 Low Low
Spinal cord 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Aging 66 99.68 Very High Very High Very High
Ganglion Cysts 6 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Lifespan 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
HCN3 expression decreases during aging in oocytes, granulosa cells of preantral follicles, and in theca cells, suggesting a possible function in the decrease of ovarian function in advancing reproductive age.
Negative_regulation (decreases) of Gene_expression (expression) of HCN3 in granulosa cells associated with aging
1) Confidence 0.44 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.78 Pain Relevance 0.14
HCN3 expression are also decreased in the granulosa cells of preantral follicles and theca cells in reproductive aging.
Negative_regulation (decreased) of Gene_expression (expression) of HCN3 in granulosa cells associated with aging
2) Confidence 0.33 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.32 Pain Relevance 0.16
HCN3 expression decreases during aging in oocytes, granulosa cells of preantral follicles, and in theca cells, suggesting a possible function in the decrease of ovarian function in advancing reproductive age.
Negative_regulation (decreases) of in oocytes Gene_expression (expression) of HCN3 in granulosa cells associated with aging
3) Confidence 0.15 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2533335 Disease Relevance 0.78 Pain Relevance 0.14

General Comments

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