INT245920

Context Info Confidence 0.09 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.36 Pain Relevance 0.26

transport (TRPV1) small molecule metabolic process (GLA) Golgi apparatus (GLA) lipid metabolic process (TRPV1) cytoplasm (GLA) cytosol (TRPV1)

GLA (Homo sapiens) TRPV1 (Homo sapiens)

Pain Link Frequency Relevance Heat Nicotine 48 92.72 agonist 54 56.76 Glutamate 84 38.00 Pain 9 5.00 alcohol 9 5.00 Acupuncture 9 5.00 Potency 9 5.00 qutenza 6 5.00 antagonist 6 5.00 medulla 3 5.00

Disease Link Frequency Relevance Heat Targeted Disruption 42 98.76 Pain 9 5.00 Aging 6 5.00 Overdose 3 5.00 Taste Disorders 3 5.00 Body Weight 3 5.00 Blister 3 5.00 Peripheral Arterial Disease 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The increase in the Bz-insensitive NaCl CT response by GalA-MRP and ethanol were additive (Figure 3D), suggesting that ethanol and GalA-MRP bind to different intracellular-binding sites on the TRPV1t receptor.

GalA Binding (bind) of TRPV1t

1) Confidence 0.09 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.03

In order to confirm that GalA-MRP produces its effect by interacting with TRPV1t, NaCl CT recordings were made in both wild-type and TRPV1 knockout mice.

GalA Binding (interacting) of TRPV1t associated with targeted disruption

2) Confidence 0.09 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.26 Pain Relevance 0

The additional proof that GalA-MRP interacts with TRPV1t is provided by the observation that TRPV1 knockout mice, that lack the Bz-insensitive component of the NaCl CT response, also do not respond to Gal-MRP (Figure 5B–D), ethanol, RTX, nicotine, and elevated temperatures (Lyall et al. 2005a, 2005c, 2007).

GalA Binding (interacts) of TRPV1t associated with targeted disruption and nicotine

3) Confidence 0.09 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.10 Pain Relevance 0.23

General Comments

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