INT245926

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.36
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC1, TRPV1) plasma membrane (ABCC1, TRPV1) small molecule metabolic process (ABCC1)
Golgi apparatus (ABCC1) lipid metabolic process (TRPV1) transmembrane transport (ABCC1)
ABCC1 (Homo sapiens)
TRPV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nicotine 48 92.72 High High
agonist 54 56.56 Quite High
Glutamate 84 38.00 Quite Low
Pain 9 5.00 Very Low Very Low Very Low
alcohol 9 5.00 Very Low Very Low Very Low
Acupuncture 9 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
qutenza 6 5.00 Very Low Very Low Very Low
antagonist 6 5.00 Very Low Very Low Very Low
medulla 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 42 98.56 Very High Very High Very High
Pain 9 5.00 Very Low Very Low Very Low
Aging 6 5.00 Very Low Very Low Very Low
Overdose 3 5.00 Very Low Very Low Very Low
Taste Disorders 3 5.00 Very Low Very Low Very Low
Body Weight 3 5.00 Very Low Very Low Very Low
Blister 3 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The increase in the Bz-insensitive NaCl CT response by GalA-MRP and ethanol were additive (Figure 3D), suggesting that ethanol and GalA-MRP bind to different intracellular-binding sites on the TRPV1t receptor.
MRP Binding (bind) of TRPV1t
1) Confidence 0.17 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0 Pain Relevance 0.03
In order to confirm that GalA-MRP produces its effect by interacting with TRPV1t, NaCl CT recordings were made in both wild-type and TRPV1 knockout mice.
MRP Binding (interacting) of TRPV1t associated with targeted disruption
2) Confidence 0.17 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.26 Pain Relevance 0
The additional proof that GalA-MRP interacts with TRPV1t is provided by the observation that TRPV1 knockout mice, that lack the Bz-insensitive component of the NaCl CT response, also do not respond to Gal-MRP (Figure 5B–D), ethanol, RTX, nicotine, and elevated temperatures (Lyall et al. 2005a, 2005c, 2007).
MRP Binding (interacts) of TRPV1t associated with targeted disruption and nicotine
3) Confidence 0.17 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.10 Pain Relevance 0.23

General Comments

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