INT245941

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Context Info
Confidence 0.26
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.61
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCC1) small molecule metabolic process (ABCC1) Golgi apparatus (ABCC1)
nucleolus (ABCC1) ATPase activity (ABCC1) plasma membrane (ABCC1)
ABCC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 28 99.08 Very High Very High Very High
COX-2 inhibitor 23 75.76 Quite High
cytokine 76 71.68 Quite High
palliative 1 67.40 Quite High
Pain 11 65.44 Quite High
Inflammation 40 50.00 Quite Low
metalloproteinase 102 5.00 Very Low Very Low Very Low
chemokine 20 5.00 Very Low Very Low Very Low
agonist 18 5.00 Very Low Very Low Very Low
Nicotine 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 35 98.72 Very High Very High Very High
Apoptosis 12 97.64 Very High Very High Very High
Prostate Cancer 52 93.52 High High
Sarcoma 79 91.16 High High
Herpes Simplex Virus 238 90.88 High High
Death 8 71.68 Quite High
Targeted Disruption 17 66.60 Quite High
Metastasis 11 66.28 Quite High
Infection 104 66.08 Quite High
Pain 11 65.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Provocative data from our team have suggested that it may be possible to modulate the impact of mitoxantrone by the use of tesmilifene, a xenobiotic that alters the function of cytochrome P450 and which alters the function of multidrug resistance protein, thus altering the exposure of tumor cells to the active agent.[14] In a phase II trial, we demonstrated a surprising proportion of patients with very advanced, AIPC to be alive at 2 and 3 years, consequent upon an initial PSA response rate of more than 60%.[14]

ESTRAMUSTINE

Regulation (alters) of multidrug resistance protein associated with cancer and prostate cancer
1) Confidence 0.26 Published 2008 Journal Indian Journal of Urology : IJU : Journal of the Urological Society of India Section Body Doc Link PMC2684340 Disease Relevance 0.46 Pain Relevance 0.13
The effect of Xyl-MRP on the CT response to MSG + Bz + SB was not observed at concentrations ?
Regulation (effect) of MRP associated with glutamate
2) Confidence 0.21 Published 2008 Journal Chemical Senses Section Body Doc Link PMC2533421 Disease Relevance 0.12 Pain Relevance 0.42
Intriguingly, we observed that COX-2/PGE2 is involved in regulating latently infected TIVE-LTC cell survival (Figure 11).
Regulation (regulating) of LTC
3) Confidence 0.00 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 1.02 Pain Relevance 0.14

General Comments

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