INT246023

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.99
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (IL6, SOCS2) cytosol (SOCS2) extracellular space (IL6)
extracellular region (IL6) cytoplasm (SOCS2)
Anatomy Link Frequency
Th17 cells 1
IL6 (Homo sapiens)
SOCS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 13 94.56 High High
Crohn's disease 37 93.44 High High
cytokine 1 92.84 High High
psoriasis 1 71.20 Quite High
spinal inflammation 1 65.60 Quite High
Bile 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 11 94.56 High High
Disease 57 93.44 High High
Inflammatory Bowel Disease 21 72.00 Quite High
Psoriasis 1 71.20 Quite High
Low Back Pain 1 65.60 Quite High
Shock 1 62.88 Quite High
Primary Sclerosing Cholangitis 21 50.00 Quite Low
Biliary Liver Cirrhosis 15 50.00 Quite Low
Syndrome 1 5.08 Very Low Very Low Very Low
Disease Susceptibility 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL23 and IL6 activate the STAT3 transcription factor which in turn leads to differentiation of CD4+ helper T cells into Th17 cells that function in driving autoimmune inflammation by producing pro-inflammatory cytokines, such as IL-17A, IL-17F and IL-22 [13,32-35].
IL6 Positive_regulation (activate) of STAT3 in Th17 cells associated with inflammation and cytokine
1) Confidence 0.18 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 0.99 Pain Relevance 0.43

General Comments

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