INT246028

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Context Info
Confidence 0.46
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.74
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (IL23R)
Anatomy Link Frequency
nucleus 1
IL23R (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 3 99.54 Very High Very High Very High
Crohn's disease 89 98.60 Very High Very High Very High
Multiple sclerosis 1 82.88 Quite High
Inflammation 35 80.88 Quite High
rheumatoid arthritis 4 78.84 Quite High
spinal inflammation 43 68.96 Quite High
psoriasis 6 64.48 Quite High
spondylitis 2 50.00 Quite Low
Bile 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 148 98.60 Very High Very High Very High
Autoimmune Disease 6 90.48 High High
Syndrome 3 87.76 High High
Demyelinating Disease 1 82.88 Quite High
Infection 1 81.68 Quite High
INFLAMMATION 26 80.88 Quite High
Diabetes Mellitus 5 79.52 Quite High
Rheumatoid Arthritis 4 78.84 Quite High
Ankylosing Spondylitis 42 68.96 Quite High
Shock 2 68.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The interleukine-23 receptor (IL23R) gene is located on chromosome region 1p31, and encodes a subunit of the IL23 receptor.
Positive_regulation (located) of IL23R
1) Confidence 0.46 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 0.92 Pain Relevance 0.40
The interleukine-23 receptor (IL23R) gene is located on chromosome region 1p31, and encodes a subunit of the IL23 receptor.
Positive_regulation (located) of interleukine-23 receptor
2) Confidence 0.46 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 0.92 Pain Relevance 0.40
In response to cytokine signaling through the IL-23R, STAT3 is activated by phosphorylation and is translocated to the nucleus where it acts as a transcriptional activator.
Positive_regulation (activated) of IL-23R in nucleus associated with cytokine
3) Confidence 0.21 Published 2010 Journal PLoS Genetics Section Body Doc Link PMC2996314 Disease Relevance 0.90 Pain Relevance 0.36

General Comments

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