INT246031

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 9.48
Pain Relevance 5.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL22) extracellular region (IL22) cell-cell signaling (IL22)
Anatomy Link Frequency
Th17 cells 3
skin 3
keratinocytes 1
IL22 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 221 100.00 Very High Very High Very High
cytokine 197 100.00 Very High Very High Very High
Arthritis 233 99.44 Very High Very High Very High
chemokine 40 98.84 Very High Very High Very High
rheumatoid arthritis 225 98.72 Very High Very High Very High
psoriasis 264 97.48 Very High Very High Very High
Osteoarthritis 20 86.80 High High
Etanercept 70 86.64 High High
Crohn's disease 37 86.48 High High
spinal inflammation 1 83.36 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 208 100.00 Very High Very High Very High
Seronegative Spondarthritis 180 99.44 Very High Very High Very High
Rheumatoid Arthritis 231 98.72 Very High Very High Very High
Hyperplasia 4 98.52 Very High Very High Very High
Psoriasis 331 97.48 Very High Very High Very High
Disease 277 95.36 Very High Very High Very High
Skin Diseases 17 92.88 High High
Arthritis 69 92.56 High High
Inflammatory Bowel Disease 31 89.76 High High
Osteoarthritis 20 86.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In turn, IL-23 sustains Th17 proliferation, hence primarily increasing levels of IL-17 and IL-22 produced by these activated Th17 cells (It has been suggested that Th0 differentiation into Th17 is originally initiated by IL-6 and TGF-?
Gene_expression (produced) of IL-22 in Th17 cells
1) Confidence 0.40 Published 2010 Journal Core Evidence Section Body Doc Link PMC2915500 Disease Relevance 0.41 Pain Relevance 0.20
Furthermore, the significantly higher circulating levels of IL-6 and IL-22 were maintained in established RA (Figure 3).
Gene_expression (levels) of IL-22 associated with rheumatoid arthritis
2) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.04 Pain Relevance 0.76
Elevated IL-22 expression in the SF of PsA patients, a novel finding in our patients, suggests that the Th17 system may have an underlying role in both skin [20] and joint involvement.
Gene_expression (expression) of IL-22 in skin associated with arthritis
3) Confidence 0.32 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 1.31 Pain Relevance 0.82
Furthermore, the significantly higher circulating levels of IL-6 and IL-22 were maintained in established RA (Figure 3).
Gene_expression (levels) of IL-22 associated with rheumatoid arthritis
4) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.04 Pain Relevance 0.76
/CCL4 as well as IL-17 and IL-22) were detected.
Gene_expression (detected) of IL-22
5) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.26 Pain Relevance 0.10
, IL-1Ra, IL-6 and IL-22 levels with respect to basal values (Figure 3).
Gene_expression (levels) of IL-22
6) Confidence 0.28 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945042 Disease Relevance 0.19 Pain Relevance 0.07
Concurrently, Th17 cells produce IL-22 and IL-17 which stimulate epidermal hyperplasia and neutrophil recruitment and further enhance inflammation.
Gene_expression (produce) of IL-22 in Th17 cells associated with inflammation and hyperplasia
7) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2933899 Disease Relevance 1.24 Pain Relevance 0.31
IL23 and IL6 activate the STAT3 transcription factor which in turn leads to differentiation of CD4+ helper T cells into Th17 cells that function in driving autoimmune inflammation by producing pro-inflammatory cytokines, such as IL-17A, IL-17F and IL-22 [13,32-35].
Gene_expression (producing) of IL-22 in Th17 cells associated with inflammation and cytokine
8) Confidence 0.04 Published 2008 Journal BMC Med Genet Section Body Doc Link PMC2535589 Disease Relevance 1.27 Pain Relevance 0.56
Further, it was demonstrated that psoriasis mediators IL-17 and IL-22 synergistically induce the production of IL-20 subfamily proteins in cultured human keratinocytes and the expression of the IL-22 receptor (IL-22R) was also increased in epidermal lesions versus normal skin.23 IL-17 and IL-22 coordinately enhanced cytokine, chemokine, and growth factor production depending on the amount of IL-22R expression.
Gene_expression (expression) of IL-22R in skin associated with chemokine, psoriasis and cytokine
9) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.94 Pain Relevance 0.46
Further, it was demonstrated that psoriasis mediators IL-17 and IL-22 synergistically induce the production of IL-20 subfamily proteins in cultured human keratinocytes and the expression of the IL-22 receptor (IL-22R) was also increased in epidermal lesions versus normal skin.23 IL-17 and IL-22 coordinately enhanced cytokine, chemokine, and growth factor production depending on the amount of IL-22R expression.
Gene_expression (expression) of IL-22R in skin associated with chemokine, psoriasis and cytokine
10) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.88 Pain Relevance 0.53
The data concluded that increased IL-22R expression in epidermal keratinocytes contributes to the pathogenesis of psoriasis through enhancing the coordinated effects of IL-22 and IL-17.
Gene_expression (expression) of IL-22R in keratinocytes associated with psoriasis
11) Confidence 0.01 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2857612 Disease Relevance 0.89 Pain Relevance 0.54

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