INT24605

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Context Info
Confidence 0.34
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 3.98
Pain Relevance 1.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Scly) cytoplasm (Scly)
Anatomy Link Frequency
SNS 2
Scly (Mus musculus)
Pain Link Frequency Relevance Heat
Multiple sclerosis 246 100.00 Very High Very High Very High
Demyelination 6 98.90 Very High Very High Very High
Fibrositis 23 98.28 Very High Very High Very High
glial activation 2 90.80 High High
tetrodotoxin 1 84.52 Quite High
Pain 5 84.40 Quite High
Central nervous system 2 77.72 Quite High
Action potential 1 73.56 Quite High
lidocaine 2 60.88 Quite High
sodium channel 1 59.84 Quite High
Disease Link Frequency Relevance Heat
Demyelinating Disease 252 100.00 Very High Very High Very High
Neurological Disease 4 98.88 Very High Very High Very High
Syndrome 2 98.56 Very High Very High Very High
Fibromyalgia 7 98.28 Very High Very High Very High
Disorder Of Lipid Metabolism 18 97.56 Very High Very High Very High
Viral Meningitis 2 92.08 High High
Peripheral Arterial Disease 6 90.48 High High
Sleep Disorders 8 87.92 High High
Neurodegenerative Disease 4 87.36 High High
Disease 40 85.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both norepinephrine (2 x 10(-9) M) and Bay K 8644 (10(-7) M) elicited a significantly greater increase in D2 than in D1, resulting in a decrease in SCL.
Negative_regulation (decrease) of SCL
1) Confidence 0.34 Published 1989 Journal Circ. Res. Section Abstract Doc Link 2467760 Disease Relevance 0 Pain Relevance 0.12
Marked increase of SEMG levels, and a decrease of TEMP and SCL were observed at the dominant side in the FMS Group, and a negative correlation of SEMG levels with TEMP and SCL was found.
Negative_regulation (decrease) of SCL associated with fibrositis
2) Confidence 0.21 Published 2006 Journal Appl Psychophysiol Biofeedback Section Abstract Doc Link 17063406 Disease Relevance 0.75 Pain Relevance 0.53
A previous proteomics study showed increased levels of apolipoprotein D in patients with a clinically isolated syndrome of demyelination, indicating that abundance levels of this protein are highest in MScl patients at the time of their first exacerbation [10], [17].
Negative_regulation (highest) of MScl associated with multiple sclerosis, demyelination, syndrome and disorder of lipid metabolism
3) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.46 Pain Relevance 0.52
Recently, a CSF proteomics study showed that serum levels of vitamin D-binding protein were decreased significantly in RR MScl patients compared to other neurological disorders[35].
Negative_regulation (decreased) of RR MScl associated with multiple sclerosis and neurological disease
4) Confidence 0.12 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2929207 Disease Relevance 1.20 Pain Relevance 0.45
RESULTS: The MBSR treatment significantly reduced basal electrodermal (skin conductance level; SCL) activity (t = 3.298, p = .005) and SCL activity during meditation (t = 4.389, p = .001), consistent with reduced SNS activation.
Negative_regulation (reduced) of SCL in SNS
5) Confidence 0.07 Published 2009 Journal J Clin Psychol Med Settings Section Body Doc Link 19277851 Disease Relevance 0.09 Pain Relevance 0
RESULTS: The MBSR treatment significantly reduced basal electrodermal (skin conductance level; SCL) activity (t = 3.298, p = .005) and SCL activity during meditation (t = 4.389, p = .001), consistent with reduced SNS activation.
Negative_regulation (reduced) of SCL in SNS
6) Confidence 0.07 Published 2009 Journal J Clin Psychol Med Settings Section Body Doc Link 19277851 Disease Relevance 0.09 Pain Relevance 0
Stimulation of both sides of the cervical vagal complexes (CVS) decreased right atrial contractile force, increased SCL, and prolonged AV interval.
Negative_regulation (decreased) of SCL
7) Confidence 0.05 Published 2000 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 10993785 Disease Relevance 0.39 Pain Relevance 0.09

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