INT246063

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.74
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 1 5.00 Very Low Very Low Very Low
Glutamate 1 5.00 Very Low Very Low Very Low
Inflammation 1 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 16 99.36 Very High Very High Very High
Death 18 82.96 Quite High
Breast Cancer 3 78.56 Quite High
Apoptosis 17 72.60 Quite High
Cancer 8 71.00 Quite High
Stress 9 5.00 Very Low Very Low Very Low
Bone Disease 3 5.00 Very Low Very Low Very Low
Leukemia 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 2 5.00 Very Low Very Low Very Low
Adenocarcinoma 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This decrease in Nrf2 protein level in response to high doses of oridonin is not due solely to cell toxicity because Keap1 or ?
Neg (not) Positive_regulation (due) of Negative_regulation (decrease) of Nrf2 protein associated with toxicity
1) Confidence 0.47 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.74 Pain Relevance 0
Furthermore, RNA interference (RNAi) depletion of SQSTM1 resulted in an increase in the protein level of Keap1 and a concomitant decrease in the protein level of Nrf2 in the absence of changes in Keap1 or Nrf2 mRNA levels.
Positive_regulation (resulted) of Negative_regulation (decrease) of Nrf2
2) Confidence 0.27 Published 2010 Journal The Journal of Biological Chemistry Section Abstract Doc Link PMC2878012 Disease Relevance 0 Pain Relevance 0

General Comments

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