INT246065

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Context Info
Confidence 0.59
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 1.01
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NFE2L2) plasma membrane (NFE2L2) nucleus (NFE2L2)
DNA binding (NFE2L2) cytoplasm (NFE2L2)
NFE2L2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 4 44.68 Quite Low
Inflammation 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 60 95.44 Very High Very High Very High
Apoptosis 68 93.96 High High
Leukemia 8 86.20 High High
Colon Cancer 4 76.96 Quite High
Cancer 32 73.24 Quite High
Breast Cancer 12 43.20 Quite Low
Sarcoma 4 36.96 Quite Low
Lung Cancer 8 18.36 Low Low
Fibrosarcoma 4 16.68 Low Low
Prostate Cancer 4 13.56 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar to tBHQ, oridonin is able to block ubiquitination and degradation of Nrf2, resulting in the prolonged half-life of Nrf2.
Negative_regulation (block) of Protein_catabolism (degradation) of Nrf2
1) Confidence 0.59 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.14 Pain Relevance 0
Similar to tert-butylhydroquinone (tBHQ), it inhibits ubiquitination and degradation of Nrf2, resulting in stabilization of Nrf2 and activation of the Nrf2 signaling pathway.
Negative_regulation (inhibits) of Protein_catabolism (degradation) of Nrf2
2) Confidence 0.43 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.46 Pain Relevance 0
Taken together, these results indicate that oridonin activates the Nrf2 pathway by inhibiting ubiquitination and degradation of Nrf2, leading to an increase in Nrf2 protein level and activation of the Nrf2-dependent response.


Negative_regulation (inhibiting) of Protein_catabolism (degradation) of Nrf2
3) Confidence 0.43 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.16 Pain Relevance 0
Oridonin activated the Nrf2 signaling pathway at a low subtoxic dose and was able to stabilize Nrf2 by blocking Nrf2 ubiquitination and degradation, leading to accumulation of the Nrf2 protein and activation of the Nrf2-dependent cytoprotective response.
Negative_regulation (blocking) of Protein_catabolism (degradation) of Nrf2
4) Confidence 0.43 Published 2008 Journal Environ Health Perspect Section Abstract Doc Link PMC2535615 Disease Relevance 0.26 Pain Relevance 0

General Comments

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