INT246073

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Context Info
Confidence 0.64
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.24
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (RUNX1) nucleus (RUNX1) DNA binding (RUNX1)
transcription factor binding (RUNX1)
Anatomy Link Frequency
cleavage 2
RUNX1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Paracetamol 2 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 34 98.88 Very High Very High Very High
Leukemia 4 95.28 Very High Very High Very High
Colon Cancer 2 86.04 High High
Cancer 16 82.32 Quite High
Toxicity 30 50.00 Quite Low
Sarcoma 2 46.04 Quite Low
Lung Cancer 4 27.44 Quite Low
Fibrosarcoma 2 25.76 Quite Low
Breast Cancer 6 24.40 Low Low
Prostate Cancer 2 22.64 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Mechanistically, oridonin induced the caspase 3–dependent cleavage of the AML1–ETO fusion protein, leading to an accelerated apoptotic response (Zhou et al. 2007b).
Protein_catabolism (cleavage) of AML1 in cleavage associated with apoptosis
1) Confidence 0.64 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.62 Pain Relevance 0
Mechanistically, oridonin induced the caspase 3–dependent cleavage of the AML1–ETO fusion protein, leading to an accelerated apoptotic response (Zhou et al. 2007b).
Protein_catabolism (cleavage) of fusion protein in cleavage associated with apoptosis
2) Confidence 0.01 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2535615 Disease Relevance 0.62 Pain Relevance 0

General Comments

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