INT24610

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Context Info
Confidence 0.70
First Reported 1988
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 1.71
Pain Relevance 2.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (CCHCR1) nucleus (CCHCR1) cytoplasm (CCHCR1)
Anatomy Link Frequency
finger 2
blood 1
heart 1
CCHCR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
narcan 4 99.70 Very High Very High Very High
noradrenaline 12 99.44 Very High Very High Very High
Catecholamine 6 98.28 Very High Very High Very High
rapifen 15 98.00 Very High Very High Very High
anesthesia 12 97.56 Very High Very High Very High
Dynorphin 2 97.40 Very High Very High Very High
Clonidine 3 95.92 Very High Very High Very High
endometriosis 65 88.04 High High
agonist 3 81.92 Quite High
cytokine 6 79.88 Quite High
Disease Link Frequency Relevance Heat
Natriuresis 2 91.88 High High
Increased Venous Pressure Under Development 3 90.88 High High
Endometriosis 71 88.04 High High
Necrosis 1 82.08 Quite High
Cancer 1 81.72 Quite High
Disease 18 78.80 Quite High
Stress 2 75.00 Quite High
Metastasis 2 70.48 Quite High
Adhesions 4 68.32 Quite High
INFLAMMATION 4 59.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dexmedetomidine increased the transmitted light through the fingertip by up to 41% +/- 8% during the dexmedetomidine infusion (P < 0.001).We demonstrated that dexmedetomidine (0.98 +/- 0.01 microg/kg) increased the plasma rocuronium concentration, decreased T1, increased SBP, and decreased finger blood flow during propofol/alfentanil anesthesia.
Positive_regulation (increased) of SBP in finger associated with rapifen and anesthesia
1) Confidence 0.70 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10072019 Disease Relevance 0.09 Pain Relevance 0.30
Phentolamine (0.07 mg X kg-1 every 10 min i.v.) and nifedipine (20 mg p.o.) increased HR and reduced SBP during the exercise.
Positive_regulation (increased) of SBP
2) Confidence 0.62 Published 1988 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468060 Disease Relevance 0 Pain Relevance 0.74
Despite administration of a single dose, significant maximal changes in SBP, DBP, and PR were achieved after drug administration for both formulations compared with baseline values (all, P < 0.001).
Positive_regulation (changes) of SBP
3) Confidence 0.49 Published 2004 Journal Clin Ther Section Body Doc Link 15220015 Disease Relevance 0 Pain Relevance 0
Dexmedetomidine increased the transmitted light through the fingertip by up to 41% +/- 8% during the dexmedetomidine infusion (P < 0.001).We demonstrated that dexmedetomidine (0.98 +/- 0.01 microg/kg) increased the plasma rocuronium concentration, decreased T1, increased SBP, and decreased finger blood flow during propofol/alfentanil anesthesia.
Positive_regulation (increased) of SBP in finger associated with rapifen and anesthesia
4) Confidence 0.47 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10072019 Disease Relevance 0.09 Pain Relevance 0.30
In the rating of subjective arousal pleasant and unpleasant stimuli received the same high score in comparison with neutral stimuli; a different cardiovascular and neuroendocrine pattern was obtained in healthy subjects: unpleasant stimuli elicited increases in HR, SBP, MHPG, NE, ACTH, CORT, whereas neutral and pleasant stimuli did not induce any significant response in hormonal levels.
Positive_regulation (increases) of SBP
5) Confidence 0.45 Published 2003 Journal Drug Alcohol Depend Section Abstract Doc Link 12821203 Disease Relevance 0 Pain Relevance 0.07
Dexmedetomidine increased SBP (P < 0.001) and decreased HR (P < 0.001) (5-min median values) during the infusion compared with values before the infusion.
Positive_regulation (increased) of SBP
6) Confidence 0.41 Published 1999 Journal Anesth. Analg. Section Abstract Doc Link 10072019 Disease Relevance 0.06 Pain Relevance 0.28
Healthy subjects were classified according to their percent increase in systolic blood pressure (SBP) after mental arithmetic test (MAT) as low (delta SBP 9.3-15.1%, n = 15) and high (delta SBP 35.1-45.4%, n = 15) responders.
Positive_regulation (increase) of SBP in blood
7) Confidence 0.24 Published 1997 Journal Peptides Section Abstract Doc Link 9149287 Disease Relevance 0.15 Pain Relevance 0.24
Pretreatment with naloxone hydrochloride enhanced (p < 0.01) SBP, heart rate, noradrenaline, cortisol, and endothelin-1 levels, and reduced (p < 0.01) ANF in low responders in response to MAT, whereas it decreased (p < 0.01) hemodynamic parameters, noradrenaline, and endothelin-1 in high responders.
Positive_regulation (enhanced) of SBP in heart associated with noradrenaline and narcan
8) Confidence 0.24 Published 1997 Journal Peptides Section Abstract Doc Link 9149287 Disease Relevance 0.17 Pain Relevance 0.44
enhances steroidogenesis via activation of StAR protein and leads to the activation of insulin-signaling pathways [42].
Positive_regulation (activation) of StAR protein
9) Confidence 0.13 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2752458 Disease Relevance 1.14 Pain Relevance 0.22

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