INT246100

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Context Info
Confidence 0.61
First Reported 2008
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.20
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Adam10) nucleocytoplasmic transport (Adam10) Golgi apparatus (Adam10)
nucleus (Adam10) cytoplasm (Adam10)
Anatomy Link Frequency
Notch 2
Adam10 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 5 71.76 Quite High
cytokine 1 59.04 Quite High
metalloproteinase 4 54.12 Quite High
Inflammation 3 53.60 Quite High
Etanercept 1 42.96 Quite Low
Pain 3 18.60 Low Low
headache 2 17.84 Low Low
Kinase C 12 5.00 Very Low Very Low Very Low
nMDA receptor 5 5.00 Very Low Very Low Very Low
Nerve growth factor 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 27 99.62 Very High Very High Very High
Disease 221 92.88 High High
Amyloid Plaque 17 90.32 High High
Cancer 5 63.12 Quite High
Necrosis 3 62.80 Quite High
Alzheimer's Dementia 14 61.68 Quite High
INFLAMMATION 4 53.60 Quite High
Congenital Anomalies 11 51.56 Quite High
Liver Disease 2 35.48 Quite Low
Body Weight 32 30.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Interestingly, low levels of cholesterol leads to high expression of Adam10, coding for a protease also known as Kuzbanian, which is essential for Notch activation [55].
Positive_regulation (leads) of Gene_expression (expression) of Adam10 in Notch
1) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
Moreover, when Adam10 is not expressed Dll1 is overexpressed [56].
Positive_regulation (overexpressed) of Neg (not) Gene_expression (expressed) of Adam10
2) Confidence 0.61 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0 Pain Relevance 0
Overexpression of ADAM10 increases ?
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of ADAM10
3) Confidence 0.32 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.25 Pain Relevance 0.05
Overexpression of ADAM10 increases ?
Positive_regulation (increases) of Gene_expression (Overexpression) of ADAM10
4) Confidence 0.32 Published 2011 Journal Mol Brain Section Body Doc Link PMC3022812 Disease Relevance 0.25 Pain Relevance 0.05
Transgenic mice that have an overexpression of disintegrin and metalloprotease-10 (ADAM-10), which activates ?
Positive_regulation (overexpression) of Gene_expression (overexpression) of metalloprotease-10 associated with targeted disruption
5) Confidence 0.22 Published 2008 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2536544 Disease Relevance 0.71 Pain Relevance 0.19

General Comments

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