INT246173

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Context Info
Confidence 0.48
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.44
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (EEF2) translation (EEF2) GTPase activity (EEF2)
cytoplasm (EEF2)
Anatomy Link Frequency
leg 1
EEF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 38 91.56 High High
addiction 2 88.84 High High
Neuropeptide 6 80.56 Quite High
Spinal cord 10 70.76 Quite High
Ventral tegmentum 3 60.48 Quite High
Calcium channel 1 35.56 Quite Low
agonist 26 5.00 Very Low Very Low Very Low
Antinociceptive 8 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
amygdala 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Premature Ejaculation 2 93.48 High High
Stress Incontinence 1 76.88 Quite High
Muscular Atrophy 52 71.92 Quite High
Frailty 14 70.16 Quite High
Hypertrophy 1 69.68 Quite High
Erectile Dysfunction 2 61.76 Quite High
Osteoporosis 3 33.44 Quite Low
Pre-term Labor 3 27.04 Quite Low
Premature Birth 1 22.68 Low Low
Autism 6 15.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Another study, however, failed to detect any significant changes in the phosphorylation of Akt, mTOR, p70S6K, eEF2, eIF4E, and TSC2 in men following 10 and 21 d of ULS [26].
Phosphorylation (phosphorylation) of eEF2
1) Confidence 0.48 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2716517 Disease Relevance 0.21 Pain Relevance 0
Specifically, the insulin dose-related increases in the phosphorylation of PKB and p70S6k and dose-dependent decreases in the phosphorylation of eEF2 are not reflected in any way by dose-related changes in MPS or leg turnover.
Phosphorylation (phosphorylation) of eEF2 in leg
2) Confidence 0.48 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
Increasing serum insulin concentration during the mixed amino acid infusion produced insulin dose-related increases in the phosphorylation status of PKB Ser473 and p70S6k Thr389 and dose-related decreases in eEF2 Thr56 phosphorylation status relative to the values at 5 mU/l (Fig. 5A).
Phosphorylation (phosphorylation) of eEF2
3) Confidence 0.48 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
Devost et al. recently demonstrated that oxytocin exerts a trophic effect on myometrial cells and that this effect is mediated by dephosphorylation and the activation of elongation factor eEF2 [138].
Phosphorylation (dephosphorylation) of eEF2
4) Confidence 0.13 Published 2010 Journal CNS Neuroscience & Therapeutics Section Body Doc Link PMC2972642 Disease Relevance 0.23 Pain Relevance 0.24

General Comments

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