INT246182

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 1.55
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
myocardium 4
spinal cord 4
fat 1
muscle 1
FBXO32 (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 8 98.18 Very High Very High Very High
agonist 1 97.06 Very High Very High Very High
Inflammation 1 89.76 High High
cytokine 24 70.60 Quite High
analgesia 8 5.00 Very Low Very Low Very Low
nalbuphine 8 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 16 97.16 Very High Very High Very High
INFLAMMATION 1 89.76 High High
Muscular Atrophy 9 85.40 High High
Coronary Heart Disease 8 79.00 Quite High
Sepsis 24 67.36 Quite High
Heart Rate Under Development 40 55.40 Quite High
Hyperinsulinism 3 43.72 Quite Low
Necrosis 8 5.00 Very Low Very Low Very Low
Cancer 8 5.00 Very Low Very Low Very Low
Pressure Volume 2 Under Development 8 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At the same time point, a significant increase in MAFbx/atrogin-1 and MuRF1 mRNA (3.7±0.7- and 19.5±1.9-fold increase vs. controls, respectively; P<0.05), in addition to protein levels of ?
Positive_regulation (increase) of Gene_expression (/) of atrogin-1
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
In further support of this notion, elevated levels of MAFbx/atrogin-1 and MuRF1 mRNA have been observed in the myocardium following chronic heart failure induced via the ligation of the left coronary artery, a condition where reduced contractile activity of the myocardium is observed [36] and, more importantly, regular exercise training has been shown to be sufficient to significantly reduce myocardial MAFbx/atrogin-1 and MuRF1 mRNA levels following experimental myocardial infarction in rats [37].
Positive_regulation (elevated) of Gene_expression (levels) of atrogin-1 in myocardium associated with myocardial infarction
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.31 Pain Relevance 0.07
In further support of this notion, elevated levels of MAFbx/atrogin-1 and MuRF1 mRNA have been observed in the myocardium following chronic heart failure induced via the ligation of the left coronary artery, a condition where reduced contractile activity of the myocardium is observed [36] and, more importantly, regular exercise training has been shown to be sufficient to significantly reduce myocardial MAFbx/atrogin-1 and MuRF1 mRNA levels following experimental myocardial infarction in rats [37].
Positive_regulation (elevated) of Gene_expression (levels) of MAFbx in myocardium associated with myocardial infarction
3) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.31 Pain Relevance 0.07
Similar observations have also been made in the gastrocnemius and soleus muscles of rats subjected to spinal cord isolation, where brief bouts of high-load isometric contractions were able to prevent the increased expression of MAFbx/atrogin-1 and MuRF1 mRNA [35].
Positive_regulation (increased) of Gene_expression (expression) of MAFbx in spinal cord associated with spinal cord
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.21 Pain Relevance 0.05
and IL-6 mRNA levels precedes increases in both MAFbx/atrogin-1 and MuRF1.
Positive_regulation (increases) of Gene_expression (/) of MAFbx
5) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.22 Pain Relevance 0.04
and IL-6 mRNA levels precedes increases in both MAFbx/atrogin-1 and MuRF1.
Positive_regulation (increases) of Gene_expression (/) of atrogin-1
6) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.22 Pain Relevance 0.04
Similar observations have also been made in the gastrocnemius and soleus muscles of rats subjected to spinal cord isolation, where brief bouts of high-load isometric contractions were able to prevent the increased expression of MAFbx/atrogin-1 and MuRF1 mRNA [35].
Positive_regulation (increased) of Gene_expression (expression) of atrogin-1 in spinal cord associated with spinal cord
7) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.21 Pain Relevance 0.05
At the same time point, a significant increase in MAFbx/atrogin-1 and MuRF1 mRNA (3.7±0.7- and 19.5±1.9-fold increase vs. controls, respectively; P<0.05), in addition to protein levels of ?
Positive_regulation (increase) of Gene_expression (/) of MAFbx
8) Confidence 0.49 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2736646 Disease Relevance 0 Pain Relevance 0
agonist-mediated switch in rat muscle fuel utilization toward increased fat oxidation also results in decreased PKB protein expression concomitantly with upregulation of MAFbx and MuRF-1 mRNA and protein expression without any obvious change in muscle protein/DNA ratio or proteasome activity (7).
Positive_regulation (upregulation) of in muscle Gene_expression (expression) of MAFbx in fat associated with agonist
9) Confidence 0.28 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.09 Pain Relevance 0.09

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