INT246193

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Context Info
Confidence 0.08
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.04
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (RPS6KB2) signal transduction (RPS6KB2) nucleus (RPS6KB2)
translation (RPS6KB2)
Anatomy Link Frequency
leg 2
RPS6KB2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 36 28.56 Quite Low
cytokine 20 5.28 Low Low
anesthesia 2 5.00 Very Low Very Low Very Low
Inflammatory response 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
Restless leg syndrome 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Parenteral administration 1 5.00 Very Low Very Low Very Low
Intractable pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 1 94.72 High High
Insulin Resistance 13 92.52 High High
Cancer 76 92.48 High High
Sarcoma 8 79.16 Quite High
Obesity 10 53.40 Quite High
Osteogenic Sarcomas 25 50.00 Quite Low
Diabetes Mellitus 11 49.08 Quite Low
Metabolic Syndrome 3 45.80 Quite Low
Cardiovascular Disease 4 38.48 Quite Low
Myocardial Infarction 2 33.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TNF-alpha infusion increased phosphorylation of p70 S6 kinase,
Positive_regulation (increased) of Phosphorylation (phosphorylation) of p70 S6 kinase
1) Confidence 0.08 Published 2008 Journal Mediators of Inflammation Section Body Doc Link PMC2615833 Disease Relevance 0.44 Pain Relevance 0
This results in decreased mTOR kinase activity, inhibited phosphorylation of downstream targets such as p70 ribosomal protein S6 kinase (S6RP) and 4E-binding protein (4E-BP1), and potentially suppression of ribosome biogenesis and protein translation [3], [17].
Positive_regulation (results) of Phosphorylation (phosphorylation) of p70 ribosomal protein S6 kinase
2) Confidence 0.05 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2882366 Disease Relevance 0.60 Pain Relevance 0
Specifically, the insulin dose-related increases in the phosphorylation of PKB and p70S6k and dose-dependent decreases in the phosphorylation of eEF2 are not reflected in any way by dose-related changes in MPS or leg turnover.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of p70S6k in leg
3) Confidence 0.01 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

General Comments

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