INT246199

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 2.18
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (GOPC) plasma membrane (GOPC) cytoplasm (GOPC)
Anatomy Link Frequency
apoptotic cell 2
GOPC (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 27 93.92 High High
tolerance 14 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
rheumatoid arthritis 6 5.00 Very Low Very Low Very Low
imagery 6 5.00 Very Low Very Low Very Low
addiction 5 5.00 Very Low Very Low Very Low
Sicca syndrome 4 5.00 Very Low Very Low Very Low
Osteoarthritis 4 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
withdrawal 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 73 100.00 Very High Very High Very High
Death 23 99.64 Very High Very High Very High
Apoptosis 33 99.42 Very High Very High Very High
Neuroblastoma 44 91.20 High High
Stress 10 88.16 High High
Glioma 28 75.92 Quite High
Malignant Neoplastic Disease 17 62.76 Quite High
Cancer 97 58.12 Quite High
Prostate Cancer 27 50.00 Quite Low
Obesity 5 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both inhibitors showed a concentration-dependent reduction of SRP72 phosphorylation (Fig. 4, A and C, *, p < 0.05).
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of Fig
1) Confidence 0.18 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0 Pain Relevance 0
Quantification of the SRP72 phosphorylation confirmed statistically significant reduction of SRP72 serine phosphorylation (Fig. 4, B and D, *, p < 0.05).
Negative_regulation (reduction) of Phosphorylation (phosphorylation) of Fig
2) Confidence 0.18 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2963399 Disease Relevance 0.05 Pain Relevance 0
Exposure of Granta cells to 30 µM parthenolide for 3 hours resulted in a significant decrease in the phosphorylation state of p65 (Fig. 6B, lane 2) which was abrogated by pretreatment with 5 mM GSH for 2 hours (Fig. 6B, lane 4).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of Fig
3) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780735 Disease Relevance 0.13 Pain Relevance 0
Exposure of Granta cells to 30 µM parthenolide for 3 hours resulted in a significant decrease in the phosphorylation state of p65 (Fig. 6B, lane 2) which was abrogated by pretreatment with 5 mM GSH for 2 hours (Fig. 6B, lane 4).
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of Fig
4) Confidence 0.18 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2780735 Disease Relevance 0.13 Pain Relevance 0
Moreover, the prostacyclin analogue Cicaprost significantly impaired Rho activation (Fig. 9C) and cofilin phosphorylation (Fig. 9D) in 1° h.AoSMCs pre-treated with siRNATP?
Negative_regulation (impaired) of Phosphorylation (phosphorylation) of Fig
5) Confidence 0.10 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0
Stimulation of 1° h.AoSMCs also led to rapid F-actin polymerization (Fig. 6B) and cofilin phosphorylation with optimal responses generated using 1 ?
Negative_regulation (polymerization) of Phosphorylation (phosphorylation) of Fig
6) Confidence 0.10 Published 2008 Journal Cellular Signalling Section Body Doc Link PMC2681257 Disease Relevance 0 Pain Relevance 0.11
However, PD98059 partially blocked ERK phosphorylation at 1 µM or 10 µM of RA (Fig. 3).


Negative_regulation (blocked) of Phosphorylation (phosphorylation) of Fig associated with rheumatoid arthritis
7) Confidence 0.08 Published 2010 Journal Nutrition Research and Practice Section Body Doc Link PMC2933444 Disease Relevance 1.25 Pain Relevance 0
We observed a decrease in phosphorylation of PI3K, AKT and FOXO3a (Ser318) (Fig. 4A) protein along with decreased activity of Cdk2 (Fig. 3B) with the RNAi treatments.
Negative_regulation (decrease) of Phosphorylation (phosphorylation) of Fig
8) Confidence 0.07 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.25 Pain Relevance 0
Increasing serum insulin concentration during the mixed amino acid infusion produced insulin dose-related increases in the phosphorylation status of PKB Ser473 and p70S6k Thr389 and dose-related decreases in eEF2 Thr56 phosphorylation status relative to the values at 5 mU/l (Fig. 5A).
Negative_regulation (decreases) of Phosphorylation (phosphorylation) of Fig
9) Confidence 0.06 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
And P38/JUNK-mediated apoptotic cell death was prevented by inhibition of their phosphorylation (Fig. 2B).
Negative_regulation (inhibition) of Phosphorylation (phosphorylation) of Fig in apoptotic cell associated with apoptosis and death
10) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.38 Pain Relevance 0
The addition of DHT to C-33 cells decreased PAcP expression and increased Her2 phosphorylation (Fig. 3A).
Negative_regulation (decreased) of Phosphorylation (phosphorylation) of Fig
11) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2812491 Disease Relevance 0 Pain Relevance 0

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