INT246201

Context Info Confidence 0.41 First Reported 2008 Last Reported 2009 Negated 0 Speculated 1 Reported most in Body Documents 5 Total Number 9 Disease Relevance 1.27 Pain Relevance 0.25

Anatomy Link Frequency myocardium 4 spinal cord 4 muscle 2 FBXO32 (Homo sapiens)

Pain Link Frequency Relevance Heat Spinal cord 4 98.42 cytokine 12 81.04 agonist 5 5.00 anesthesia 5 5.00 Inflammation 5 5.00 analgesia 4 5.00 nalbuphine 4 5.00

Disease Link Frequency Relevance Heat Myocardial Infarction 8 99.04 Sepsis 12 87.28 Coronary Heart Disease 4 79.48 Hyperinsulinism 15 73.20 Heart Rate Under Development 20 55.88 Muscular Atrophy 9 51.84 Obesity 5 5.00 INFLAMMATION 5 5.00 Leukemia 5 5.00 Necrosis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In further support of this notion, elevated levels of MAFbx/atrogin-1 and MuRF1 mRNA have been observed in the myocardium following chronic heart failure induced via the ligation of the left coronary artery, a condition where reduced contractile activity of the myocardium is observed [36] and, more importantly, regular exercise training has been shown to be sufficient to significantly reduce myocardial MAFbx/atrogin-1 and MuRF1 mRNA levels following experimental myocardial infarction in rats [37].

Negative_regulation (reduce) of Gene_expression (levels) of MAFbx in myocardium associated with myocardial infarction

1) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.39 Pain Relevance 0.08

Similar observations have also been made in the gastrocnemius and soleus muscles of rats subjected to spinal cord isolation, where brief bouts of high-load isometric contractions were able to prevent the increased expression of MAFbx/atrogin-1 and MuRF1 mRNA [35].

Negative_regulation (prevent) of Gene_expression (expression) of atrogin-1 in spinal cord associated with spinal cord

2) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.21 Pain Relevance 0.05

In further support of this notion, elevated levels of MAFbx/atrogin-1 and MuRF1 mRNA have been observed in the myocardium following chronic heart failure induced via the ligation of the left coronary artery, a condition where reduced contractile activity of the myocardium is observed [36] and, more importantly, regular exercise training has been shown to be sufficient to significantly reduce myocardial MAFbx/atrogin-1 and MuRF1 mRNA levels following experimental myocardial infarction in rats [37].

Negative_regulation (reduce) of Gene_expression (levels) of atrogin-1 in myocardium associated with myocardial infarction

3) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.39 Pain Relevance 0.08

Similar observations have also been made in the gastrocnemius and soleus muscles of rats subjected to spinal cord isolation, where brief bouts of high-load isometric contractions were able to prevent the increased expression of MAFbx/atrogin-1 and MuRF1 mRNA [35].

Negative_regulation (prevent) of Gene_expression (expression) of MAFbx in spinal cord associated with spinal cord

4) Confidence 0.41 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2736646 Disease Relevance 0.21 Pain Relevance 0.05

One possible link appears to be between the altered phosphorylation of the majority of the signaling molecules at 30 mU/l insulin and above and the decreased expression of MAFbx and possibly the C2 proteasome subunit.

Spec (possibly) Negative_regulation (decreased) of Gene_expression (expression) of MAFbx

5) Confidence 0.35 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0.07 Pain Relevance 0

In all cases, the rate of LPB was lower than in the postabsorptive condition, except when insulin was maintained at the postabsorptive concentration, which is consonant with the 40% reduction in MAFbx expression; however, further decreases in the expression of MAFbx protein were not associated with any physiological effect on protein breakdown.

Negative_regulation (decreases) of Gene_expression (expression) of MAFbx protein

6) Confidence 0.35 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

In all cases, the rate of LPB was lower than in the postabsorptive condition, except when insulin was maintained at the postabsorptive concentration, which is consonant with the 40% reduction in MAFbx expression; however, further decreases in the expression of MAFbx protein were not associated with any physiological effect on protein breakdown.

Negative_regulation (reduction) of Gene_expression (expression) of MAFbx

7) Confidence 0.31 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

These included the dose-related increases in the extent of phosphorylation of PKB and p70S6k without any change in muscle protein synthesis and the dose-related decreases in expression of MAFbx and C2 proteasome subunit protein without any change in muscle protein breakdown.

Negative_regulation (decreases) of Gene_expression (expression) of MAFbx in muscle

8) Confidence 0.26 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

Increasing serum insulin concentrations to 30, 72, and 167 mU/l produced graded dose-related reductions in MAFbx protein expression to 40 (P < 0.05), 25 (P = 0.01), and 18% (P < 0.01), respectively, of values measured at 5 mU/l (Fig. 6).

Negative_regulation (reductions) of Gene_expression (expression) of MAFbx protein

9) Confidence 0.26 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0

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