INT24622

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Context Info
Confidence 0.69
First Reported 1984
Last Reported 2000
Negated 1
Speculated 0
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 0.32
Pain Relevance 6.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Insr) endosome (Insr) plasma membrane (Insr)
nucleus (Insr)
Anatomy Link Frequency
ACE 4
NIL 2
Insr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 21 100.00 Very High Very High Very High
dexamethasone 8 99.98 Very High Very High Very High
Substantia nigra 2 99.82 Very High Very High Very High
substance P 5 99.60 Very High Very High Very High
Enkephalin 21 99.52 Very High Very High Very High
Dopamine 5 99.36 Very High Very High Very High
cocaine 7 99.24 Very High Very High Very High
amygdala 15 99.20 Very High Very High Very High
Calcitonin gene-related peptide 3 99.08 Very High Very High Very High
tetrodotoxin 8 98.84 Very High Very High Very High
Disease Link Frequency Relevance Heat
Convulsion 6 86.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IR-LE and IR-OC release was enhanced 4 h later (20:00 h), no changes were detected for IR-HE.
Positive_regulation (enhanced) of Localization (release) of IR-LE
1) Confidence 0.69 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.55
IR-LE and IR-OC release was enhanced 4 h later (20:00 h), no changes were detected for IR-HE.
Positive_regulation (enhanced) of Localization (release) of IR-OC
2) Confidence 0.50 Published 1998 Journal Neuropeptides Section Abstract Doc Link 10189066 Disease Relevance 0 Pain Relevance 0.55
Both assays detected an age-related decline in the circulating IR-GH concentration, an increase in IR-GH secretion following TRH-stimulation or fasting, and a fall in the IR-GH concentration following adrenocorticotropin administration.
Positive_regulation (increase) of Localization (secretion) of IR-GH
3) Confidence 0.49 Published 1987 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3026886 Disease Relevance 0 Pain Relevance 0.07
Chemical stimulation of the substantia nigra with K+ enhanced four times the Met-IR release in the ipsilateral ACE.
Positive_regulation (enhanced) of Localization (release) of Met-IR in ACE associated with substantia nigra and amygdala
4) Confidence 0.48 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3561724 Disease Relevance 0 Pain Relevance 0.49
The K+ evoked release of ME-IR is also slightly enhanced by exposing the slices to dopamine.
Positive_regulation (enhanced) of Localization (release) of ME-IR associated with dopamine
5) Confidence 0.44 Published 1984 Journal Brain Res. Section Abstract Doc Link 6697225 Disease Relevance 0 Pain Relevance 0.51
In fetal cerebrocortical cells, potassium (30 and 56 mM) decreased protein synthesis and RNA levels and increased IR-SRIF release.
Positive_regulation (increased) of Localization (release) of IR-SRIF
6) Confidence 0.39 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2468735 Disease Relevance 0 Pain Relevance 0.36
Veratridine, a depolarizing agent, also stimulated the release of ME-IR.
Positive_regulation (stimulated) of Localization (release) of ME-IR
7) Confidence 0.38 Published 1984 Journal Peptides Section Abstract Doc Link 6209687 Disease Relevance 0 Pain Relevance 0.62
Veratridine-induced ME-IR release was completely prevented by tetrodotoxin (TTX), a Na+ channel blocker.
Positive_regulation (induced) of Localization (release) of ME-IR associated with tetrodotoxin
8) Confidence 0.38 Published 1984 Journal Peptides Section Abstract Doc Link 6209687 Disease Relevance 0 Pain Relevance 0.63
Both assays detected an age-related decline in the circulating IR-GH concentration, an increase in IR-GH secretion following TRH-stimulation or fasting, and a fall in the IR-GH concentration following adrenocorticotropin administration.
Positive_regulation (increase) of Localization (secretion) of IR-GH
9) Confidence 0.35 Published 1987 Journal Gen. Comp. Endocrinol. Section Abstract Doc Link 3026886 Disease Relevance 0 Pain Relevance 0.07
VIP (10(-7) M) induced a moderate release of G-IR, whereas substance P, calcitonin gene-related peptide, peptide YY, somatostatin, and neurotensin were without effect.
Positive_regulation (induced) of Localization (release) of G-IR associated with somatostatin, calcitonin gene-related peptide and substance p
10) Confidence 0.35 Published 2000 Journal Endocrinology Section Abstract Doc Link 10875263 Disease Relevance 0 Pain Relevance 0.25
The release of IR-BE from the AP and the NIL was determined in vitro and was found to be increased by treatment with cocaine.
Positive_regulation (increased) of Localization (release) of IR-BE in NIL associated with cocaine
11) Confidence 0.33 Published 1988 Journal Life Sci. Section Abstract Doc Link 2969443 Disease Relevance 0 Pain Relevance 0.37
Forskolin (10(-5) M) or sodium nitroprusside (10(-4)-10(-3) M) induced a significant release of G-IR.
Positive_regulation (induced) of Localization (release) of G-IR
12) Confidence 0.31 Published 2000 Journal Endocrinology Section Abstract Doc Link 10875263 Disease Relevance 0 Pain Relevance 0.21
In contrast, PMA (10(-7) M) or ionophore A23187 (10(-6) M) did not modify basal secretion of G-IR.
Neg (not) Positive_regulation (modify) of Localization (secretion) of G-IR
13) Confidence 0.31 Published 2000 Journal Endocrinology Section Abstract Doc Link 10875263 Disease Relevance 0 Pain Relevance 0.20
In fetal cerebrocortical cells, potassium (30 and 56 mM) decreased protein synthesis and RNA levels and increased IR-SRIF release.
Positive_regulation (increased) of Localization (release) of IR-SRIF
14) Confidence 0.28 Published 1989 Journal J. Neurochem. Section Abstract Doc Link 2468735 Disease Relevance 0 Pain Relevance 0.36
Depolarizing stimuli, such as 56 mM K+ concentration for 24 hours, elicited an increase in immunoreactive somatostatin (IR-SS) release to the media and SS mRNA levels, suggesting that somatostatin secretion can be coupled to SS mRNA accumulation.
Positive_regulation (increase) of Localization (release) of IR-SS associated with somatostatin
15) Confidence 0.10 Published 1993 Journal J Pediatr Endocrinol Section Abstract Doc Link 7920985 Disease Relevance 0 Pain Relevance 0.31
The effect of DM was dose-related and time-dependent, with an EC50 of about 1 nM; at this concentration DM enhanced ir-beta EP secretion about 2.1 times (P < 0.01) above that induced by 10 microM of forskolin alone.
Positive_regulation (enhanced) of Localization (secretion) of ir-beta associated with dexamethasone
16) Confidence 0.08 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522925 Disease Relevance 0 Pain Relevance 0.42
Long-term pharmacological kindling increases in vitro release of IR-Met and IR-Leu-enkephalin from amygdala.
Positive_regulation (increases) of Localization (release) of IR-Met in amygdala associated with enkephalin and amygdala
17) Confidence 0.06 Published 1998 Journal Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. Section Title Doc Link 9773507 Disease Relevance 0.32 Pain Relevance 0.90

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