INT246314

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Context Info
Confidence 0.60
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 0.79
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Dio2)
Anatomy Link Frequency
nerve 1
Dio2 (Mus musculus)
Dio2 - T92A (1)
Pain Link Frequency Relevance Heat
Action potential 11 98.88 Very High Very High Very High
depression 6 6.88 Low Low
Pain 3 6.40 Low Low
Calcium channel 2 5.00 Very Low Very Low Very Low
tetrodotoxin 1 5.00 Very Low Very Low Very Low
withdrawal 1 5.00 Very Low Very Low Very Low
conotoxin 1 5.00 Very Low Very Low Very Low
Buprenorphine 1 5.00 Very Low Very Low Very Low
isoflurane 1 5.00 Very Low Very Low Very Low
Sciatic nerve 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 2 94.44 High High
Thyroid Disease 10 89.84 High High
Targeted Disruption 4 78.88 Quite High
Obesity 4 73.36 Quite High
Anxiety Disorder 4 65.48 Quite High
Hypertension 2 53.16 Quite High
Insulin Resistance 2 51.88 Quite High
Increased Venous Pressure Under Development 5 48.76 Quite Low
Body Weight 2 8.80 Low Low
Fatigue 2 7.60 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
According to one large study, this could be explained by the Thr92Ala polymorphism in the DIO2 gene, which is present in about 15% of the general population.
Gene_expression (present) of DIO2 (T92A)
1) Confidence 0.60 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950057 Disease Relevance 0.44 Pain Relevance 0
However, what could be the mechanistic basis for such findings given that the DIO2 polymorphism did not affect thyrotropin, T4, or T3 serum levels in the Panicker et al. study?
Gene_expression (polymorphism) of DIO2
2) Confidence 0.58 Published 2010 Journal F1000 Med Rep Section Body Doc Link PMC2950057 Disease Relevance 0.36 Pain Relevance 0
Only when both 4-Di-2-ASP labelling and an extracellular nerve action potential were present was the absence of detectable synaptic events taken as a significant negative finding.


Gene_expression (labelling) of 4-Di-2-ASP in nerve associated with action potential
3) Confidence 0.04 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0 Pain Relevance 0.14

General Comments

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