INT246317

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 0.74
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
brain 2
neuronal 1
nerve 1
synapses 1
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 54 99.70 Very High Very High Very High
Thalamus 9 98.80 Very High Very High Very High
GABAergic 90 97.82 Very High Very High Very High
Pyramidal cell 31 94.28 High High
Calcium channel 19 73.00 Quite High
Hippocampus 27 68.08 Quite High
Neuropeptide 30 65.20 Quite High
Action potential 40 62.00 Quite High
Central nervous system 7 9.64 Low Low
Cholecystokinin 24 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 2 98.92 Very High Very High Very High
Shock 3 82.56 Quite High
Wrinkles 1 77.68 Quite High
Convulsion 52 75.92 Quite High
Cerebral Palsy 1 75.72 Quite High
Dystonia 2 74.96 Quite High
Body Weight 17 51.52 Quite High
Ganglion Cysts 9 39.28 Quite Low
Attention Deficit Hyperactivity Disorder 20 25.00 Low Low
Anxiety Disorder 16 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical analysis of SNAP-25 showed a similar appearance in homozygous neo-containing SNAP-25b deficient mutant and WT mouse brain at PN14, and no obvious pathological changes were observed (Figure 1E).
Positive_regulation (appearance) of SNAP-25b in brain
1) Confidence 0.50 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0 Pain Relevance 0
Our results demonstrate that removal of Tkneo restores SNAP-25 expression and moderately increases total SNAP-25 protein levels in brain of homozygous neo-excised SNAP-25b deficient mutants.


Positive_regulation (increases) of SNAP-25 protein in brain
2) Confidence 0.50 Published 2008 Journal PLoS Genetics Section Body Doc Link PMC2581893 Disease Relevance 0.11 Pain Relevance 0
The SNAP-25 polypeptide is encoded by a single copy gene, but in higher vertebrates a duplication of exon 5 has resulted in two mutually exclusive splice variants, SNAP-25a and SNAP-25b.
Positive_regulation (resulted) of SNAP-25b
3) Confidence 0.47 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581893 Disease Relevance 0.08 Pain Relevance 0.07
The SNAP-25 polypeptide is encoded by a single copy gene, but in higher vertebrates a duplication of exon 5 has resulted in two mutually exclusive splice variants, SNAP-25a and SNAP-25b.
Positive_regulation (resulted) of SNAP-25a
4) Confidence 0.47 Published 2008 Journal PLoS Genetics Section Abstract Doc Link PMC2581893 Disease Relevance 0.07 Pain Relevance 0.07
Synaptogenesis and maturation of functional synaptic connectivity is accompanied by dramatically increased levels of SNAP-25 [14], as well as a significant change in the relative expression of transcripts encoding two isoforms of the protein that are produced by alternative splicing between divergent, tandem arranged copies of a single exon [15].
Positive_regulation (increased) of SNAP-25
5) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.10
Between the neuronal populations surveyed, GABAergic neurons of the reticular nucleus of the thalamus exhibited a high level SNAP-25 isoform RNA expression with SNAP-25a being significantly increased compared with glutamatergic populations of cerebellar granule cells (p < 0.01) and SNAP-25b transcripts at greater abundance than hippocampal pyramidal neurons (p < 0.05), indicating that the absolute expression levels of SNAP-25 isoforms were also not tightly correlated with excitatory or inhibitory synaptic transmission.
Positive_regulation (increased) of SNAP-25a in neuronal associated with pyramidal cell, gabaergic and thalamus
6) Confidence 0.47 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2600647 Disease Relevance 0 Pain Relevance 0.29
It then specifically cleaves SNAP-25, an essential protein in exocytosis, thus preventing the ‘quantal’ release of ACh in response to nerve impulses (Schiavo et al. 2000).
Positive_regulation (cleaves) of SNAP-25 in nerve
7) Confidence 0.22 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.23 Pain Relevance 0
Syntaxin-1, SNAP-25, and VAMP-2 were reacted in the presence of either the PKA-phosphorylated form or nonphosphorylated form of tomosyn.
Positive_regulation (reacted) of SNAP-25
8) Confidence 0.12 Published 2008 Journal The Journal of Cell Biology Section Body Doc Link PMC2568027 Disease Relevance 0 Pain Relevance 0.03
In mice, monocular deprivation increases levels of SNAP-25 and SynCAM (synaptic cell adhesion molecule) transcripts [78], both of which are required for synaptogenesis [79-81].
Positive_regulation (increases) of SNAP-25 associated with adhesions
9) Confidence 0.11 Published 2011 Journal Behav Brain Funct Section Body Doc Link PMC3023691 Disease Relevance 0.10 Pain Relevance 0
Since hypertonic sucrose application is still capable of triggering neurotransmitter release at hippocampal synapses lacking the SNARE-protein SNAP-25 [37], we aimed to determine if LILFU-1 was capable of stimulating neurotransmitter release after cleaving SNAP-25 by treating slice cultures with botulinum neurotoxin type-A (BoNT/A; 24–36 h).
Positive_regulation (cleaving) of SNAP-25 in synapses associated with neurotransmitter
10) Confidence 0.10 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2568804 Disease Relevance 0.15 Pain Relevance 0.13

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