INT246318

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.34
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Snap25) plasma membrane (Snap25) cytoplasm (Snap25)
Anatomy Link Frequency
nerve 2
cleavage 2
Snap25 (Mus musculus)
Pain Link Frequency Relevance Heat
Spinal cord 46 50.00 Quite Low
Action potential 16 5.00 Very Low Very Low Very Low
tetrodotoxin 15 5.00 Very Low Very Low Very Low
Central nervous system 6 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
Neurotransmitter 4 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Calcium channel 3 5.00 Very Low Very Low Very Low
sodium channel 1 5.00 Very Low Very Low Very Low
conotoxin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Wrinkles 1 77.68 Quite High
Cerebral Palsy 1 75.72 Quite High
Dystonia 2 74.96 Quite High
Targeted Disruption 6 56.08 Quite High
Toxicity 1 55.48 Quite High
Anaerobic Bacterial Infections 22 50.00 Quite Low
Paralysis 8 5.00 Very Low Very Low Very Low
Congenital Anomalies 8 5.00 Very Low Very Low Very Low
Disease 6 5.00 Very Low Very Low Very Low
Poisoning 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It then specifically cleaves SNAP-25, an essential protein in exocytosis, thus preventing the ‘quantal’ release of ACh in response to nerve impulses (Schiavo et al. 2000).
Negative_regulation (preventing) of Protein_catabolism (cleaves) of SNAP-25 in nerve
1) Confidence 0.19 Published 2008 Journal The Journal of Physiology Section Body Doc Link PMC2538785 Disease Relevance 0.23 Pain Relevance 0
Moreover, competition of HCR/T with BoNT/E in hippocampal neurons reduced the extent of cleavage of SNAP-25 (Figure 4C).
Negative_regulation (reduced) of Protein_catabolism (cleavage) of SNAP-25 in cleavage
2) Confidence 0.16 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2991259 Disease Relevance 0.11 Pain Relevance 0

General Comments

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