INT246406

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 5
Total Number 10
Disease Relevance 3.79
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SETBP1) DNA binding (SETBP1)
Anatomy Link Frequency
immune system 3
spores 1
SETBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 70 92.88 High High
Inflammatory response 12 91.80 High High
Potency 40 88.92 High High
abdominal pain 6 84.80 Quite High
antagonist 6 38.08 Quite Low
Pain 8 17.60 Low Low
ketamine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 76 99.40 Very High Very High Very High
Communicable Diseases 12 98.68 Very High Very High Very High
Hypersensitivity 6 98.20 Very High Very High Very High
Toxicity 52 94.96 High High
INFLAMMATION 12 91.44 High High
Respiratory Failure 6 91.12 High High
Heart Rate Under Development 6 90.16 High High
Gastroenteritis 48 89.48 High High
Diarrhoea 6 85.36 High High
Abdominal Pain 6 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since it has the potential to be weaponized and used as an incapacitating or lethal agent, the National Institute of Allergy and Infectious Diseases (NIAID) and the Centers for Disease Control and Prevention (CDC) recognize SEB as a category B agent.
SEB Binding (recognize) of associated with communicable diseases, hypersensitivity and disease
1) Confidence 0.43 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 1.31 Pain Relevance 0.12
All three HuMAbs recognized the 28 kD SEB in the cell lysate without binding any other cellular protein (Figure 2) demonstrating the specificity of these HuMAbs.
SEB Binding (recognized) of
2) Confidence 0.43 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0.04
g/ml and coupled to the surface of a research-grade CM5 chip (Biacore, Inc., Piscataway, NJ) by standard amine chemistry (NHS-EDC, Biacore, Inc.), to a level of 50-250 RU of SEB bound.
SEB Binding (bound) of
3) Confidence 0.33 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0
In an immunoblotting experiment, our HuMAbs bound SEB mixed in a cell lysate and did not bind any of the lysate proteins.
SEB Binding (bound) of
4) Confidence 0.32 Published 2010 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC3022601 Disease Relevance 0.06 Pain Relevance 0.12
Additional SPR analysis using a competitive binding format revealed that HuMAb-154 and HuMAb-100C9 shared the epitope or at least have epitopes in close proximity to one another since HuMAb-100C9 cannot bind SEB that has been saturated with HuMAb-154 (data not shown).


SEB Neg (cannot) Binding (bind) of
5) Confidence 0.29 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.06 Pain Relevance 0.17
Challenge controls were injected with SEB alone and LPS alone.
SEB Binding (injected) of
6) Confidence 0.29 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.09 Pain Relevance 0
Each group was challenged by aerosol with either BoNT/A, SEB, or B. anthracis (Ames) spores and monitored for up to 2 months post-challenge.
SEB Binding (aerosol) of in spores
7) Confidence 0.08 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.83 Pain Relevance 0.12
Secreted SEB binds and cross-links class II molecules of the major histocompatibility complex expressed on antigen-presenting cells to the antigen receptors on T cells, leading to potent activation of the immune system.
SEB Binding (links) of in immune system
8) Confidence 0.08 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.48 Pain Relevance 0.04
Secreted SEB binds and cross-links class II molecules of the major histocompatibility complex expressed on antigen-presenting cells to the antigen receptors on T cells, leading to potent activation of the immune system.
SEB Binding (cross) of in immune system
9) Confidence 0.08 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.48 Pain Relevance 0.04
Secreted SEB binds and cross-links class II molecules of the major histocompatibility complex expressed on antigen-presenting cells to the antigen receptors on T cells, leading to potent activation of the immune system.
SEB Binding (binds) of in immune system
10) Confidence 0.08 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.48 Pain Relevance 0.04

General Comments

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