INT246407

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Context Info
Confidence 0.72
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 8
Disease Relevance 0.82
Pain Relevance 0.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (SETBP1) DNA binding (SETBP1)
Anatomy Link Frequency
lymphocytes 1
immune system 1
SETBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 78 99.20 Very High Very High Very High
Potency 43 92.72 High High
Pain 2 17.96 Low Low
abdominal pain 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gastroenteritis 12 89.84 High High
Toxicity 57 82.72 Quite High
Septic Shock 10 82.00 Quite High
Death 42 75.20 Quite High
Anaerobic Bacterial Infections 22 62.00 Quite High
Communicable Diseases 14 60.64 Quite High
Pressure And Volume Under Development 2 58.20 Quite High
Bacillus Anthracis Infection 13 53.84 Quite High
Yersinia Infection 13 50.00 Quite Low
Disease 30 49.76 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine the biological activity of HuMAbs in vitro, a cell-based assay was employed that measures inhibitory effects on SEB-induced secretion of proinflammatory cytokines by human peripheral blood lymphocytes.
Localization (secretion) of SEB-induced in lymphocytes associated with cytokine
1) Confidence 0.72 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.08 Pain Relevance 0.21
Individual hybridoma clones were screened by SEB-specific ELISA (Recombinant SEB, highly purified, from Toxin Technology, Inc.) for specific SEB-reactive antibodies.
Localization (screened) of SEB
2) Confidence 0.67 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.06 Pain Relevance 0
Various 4x concentrations of HuMAbs or combination thereof at different ratios were incubated with SEB (4x its in vitro ED50, data not shown) for 1 h and the mixture subsequently added to the PBMCs (1x final concentration for both HuMAbs and SEB).
Localization (concentration) of SEB
3) Confidence 0.67 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.06 Pain Relevance 0.04
Individual hybridoma clones were screened by SEB-specific ELISA (Recombinant SEB, highly purified, from Toxin Technology, Inc.) for specific SEB-reactive antibodies.
Localization (screened) of SEB
4) Confidence 0.67 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0.06 Pain Relevance 0
In an in vitro cell-based assay, these HuMAbs could inhibit SEB-induced secretion of the proinflammatory cytokines (INF-?
Localization (secretion) of SEB-induced associated with cytokine
5) Confidence 0.63 Published 2010 Journal J Immune Based Ther Vaccines Section Abstract Doc Link PMC3022601 Disease Relevance 0.08 Pain Relevance 0.13
SEB was immobilized on a CM5 chip followed by injections at various concentrations of HuMAb.
Localization (immobilized) of SEB
6) Confidence 0.58 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0.04
STEB reactive hybridoma clones were further screened against SEB as well as a panel of nonrelated antigens to confirm reactivity and determine specificity.
Localization (screened) of SEB
7) Confidence 0.58 Published 2010 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC3022601 Disease Relevance 0 Pain Relevance 0.03
Secreted SEB binds and cross-links class II molecules of the major histocompatibility complex expressed on antigen-presenting cells to the antigen receptors on T cells, leading to potent activation of the immune system.
Localization (Secreted) of SEB in immune system
8) Confidence 0.16 Published 2008 Journal J Immune Based Ther Vaccines Section Body Doc Link PMC2543000 Disease Relevance 0.48 Pain Relevance 0.04

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