INT246413

Context Info Confidence 0.28 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.81 Pain Relevance 0.05

signal transduction (TLR4, TLR3) intracellular (TLR4, TLR3) cytoplasm (TLR4, TLR3) endosome (TLR3) endoplasmic reticulum (TLR3) plasma membrane (TLR4)

TLR4 (Homo sapiens) TLR3 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 21 96.32 cytokine 8 24.16 Inflammation 15 23.76 pain pelvic 1 5.00 Dismenorea 1 5.00

Disease Link Frequency Relevance Heat Uterine Diseases 5 99.84 Endometriosis (extended) 38 96.32 Reprotox - General 3 4 92.68 Stomach Cancer 1 86.64 Genetic Predisposition To Disease 1 66.84 Endometrial Cancer 4 64.76 Endometriosis 12 63.12 Disease 3 47.44 Carcinoma 8 35.96 INFLAMMATION 15 23.76

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Our data suggest an involvement of TLR3 and TLR4 in endometrial diseases as we demonstrated altered expression levels for both receptors in endometriosis and endometrial adenocarcinoma.

TLR4 Regulation (involvement) of TLR3 associated with endometriosis, endometriosis (extended) and uterine diseases

1) Confidence 0.28 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.81 Pain Relevance 0.05

General Comments

This test has worked.