INT246420

Context Info Confidence 0.57 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.79 Pain Relevance 0.11

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3) intracellular (TLR3) cytoplasm (TLR3)

Anatomy Link Frequency endometrium 2 TLR3 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 42 99.40 Inflammation 30 65.36 cytokine 16 5.00 pain pelvic 2 5.00 Dismenorea 2 5.00

Disease Link Frequency Relevance Heat Endometriosis (extended) 76 99.40 Carcinoma 16 90.12 Malignant Neoplastic Disease 4 88.76 INFLAMMATION 30 65.36 Endometrial Cancer 8 59.76 Hyperplasia 6 58.72 Adenocarcinoma 14 46.40 Endometriosis 24 5.00 Uterine Diseases 10 5.00 Reprotox - General 3 8 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the current study, we report that toll-like receptor 3 and 4 expression is modulated in pathogenic alterations of the endometrium.

Regulation (modulated) of Gene_expression (expression) of toll-like receptor 3 in endometrium

1) Confidence 0.57 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.69 Pain Relevance 0.06

TLR3 and TLR4 expression is deregulated in peritoneal endometriosis

Regulation (deregulated) of Gene_expression (expression) of TLR3 associated with endometriosis

2) Confidence 0.42 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.10 Pain Relevance 0.05

General Comments

This test has worked.