INT246423

Context Info Confidence 0.40 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 2.20 Pain Relevance 0.60

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3) intracellular (TLR3) cytoplasm (TLR3)

Anatomy Link Frequency epithelial cells 1 endometrium 1 TLR3 (Homo sapiens)

Pain Link Frequency Relevance Heat endometriosis 63 99.38 cytokine 24 97.68 Inflammation 45 85.92 pain pelvic 3 5.00 Dismenorea 3 5.00

Disease Link Frequency Relevance Heat Endometriosis (extended) 114 99.38 Disease 9 99.12 Endometriosis 36 88.08 Carcinoma 24 87.64 INFLAMMATION 45 85.92 Endometrial Cancer 12 72.16 Genetic Predisposition To Disease 3 68.08 Necrosis 6 51.24 Reprotox - General 3 12 50.88 Infection 6 37.36

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In endometriosis, we can observe a significant decrease in TLR3 and TLR4 mRNA levels in eutopic tissues collected during the proliferative phase, when compared to controls (P < 0.05; figure 3A–B).

Negative_regulation (decrease) of TLR3 associated with endometriosis

1) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.31 Pain Relevance 0.08

Interestingly, Th2 cytokines were shown to play an important role in balancing TLR signalling in human intestinal epithelial cells by mediating downregulation of TLR3 and TLR4 expression and function [42].

Negative_regulation (downregulation) of TLR3 in epithelial cells associated with cytokine

2) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.67 Pain Relevance 0.34

In both conditions, TLR3 and TLR4 were significantly decreased in diseased endometrium when compared to age matched controls.

Negative_regulation (decreased) of TLR3 in endometrium

3) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.23 Pain Relevance 0.18

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