INT246423

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.20
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (TLR3) signal transduction (TLR3) endoplasmic reticulum (TLR3)
intracellular (TLR3) cytoplasm (TLR3)
Anatomy Link Frequency
epithelial cells 1
endometrium 1
TLR3 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 63 99.38 Very High Very High Very High
cytokine 24 97.68 Very High Very High Very High
Inflammation 45 85.92 High High
pain pelvic 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 114 99.38 Very High Very High Very High
Disease 9 99.12 Very High Very High Very High
Endometriosis 36 88.08 High High
Carcinoma 24 87.64 High High
INFLAMMATION 45 85.92 High High
Endometrial Cancer 12 72.16 Quite High
Genetic Predisposition To Disease 3 68.08 Quite High
Necrosis 6 51.24 Quite High
Reprotox - General 3 12 50.88 Quite High
Infection 6 37.36 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In endometriosis, we can observe a significant decrease in TLR3 and TLR4 mRNA levels in eutopic tissues collected during the proliferative phase, when compared to controls (P < 0.05; figure 3A–B).
Negative_regulation (decrease) of TLR3 associated with endometriosis
1) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.31 Pain Relevance 0.08
Interestingly, Th2 cytokines were shown to play an important role in balancing TLR signalling in human intestinal epithelial cells by mediating downregulation of TLR3 and TLR4 expression and function [42].
Negative_regulation (downregulation) of TLR3 in epithelial cells associated with cytokine
2) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.67 Pain Relevance 0.34
In both conditions, TLR3 and TLR4 were significantly decreased in diseased endometrium when compared to age matched controls.
Negative_regulation (decreased) of TLR3 in endometrium
3) Confidence 0.40 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 1.23 Pain Relevance 0.18

General Comments

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