INT246424

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Context Info
Confidence 0.41
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.52
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TLR4) plasma membrane (TLR4) intracellular (TLR4)
cytoplasm (TLR4)
Anatomy Link Frequency
epithelial cells 2
cornea 2
TLR4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 17 74.20 Quite High
cytokine 17 72.16 Quite High
endometriosis 21 5.00 Very Low Very Low Very Low
Inflammatory response 11 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
pain pelvic 1 5.00 Very Low Very Low Very Low
chemokine 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypersensitivity 1 96.08 Very High Very High Very High
Herpes Simplex Virus 2 94.40 High High
INFLAMMATION 28 74.20 Quite High
Bacterial Respiratory Disease 1 63.68 Quite High
Infection 2 52.32 Quite High
Carcinoma 8 39.20 Quite Low
Malignant Neoplastic Disease 2 37.84 Quite Low
Necrosis 2 24.40 Low Low
Endometrial Cancer 4 8.84 Low Low
Hyperplasia 3 7.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent study performed on bovine endometrial cells, co-localised TLR4 transcripts with CD14 mRNA and protein to stromal and epithelial cells [35].
Negative_regulation (localised) of Transcription (transcripts) of TLR4 in epithelial cells
1) Confidence 0.41 Published 2008 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2543020 Disease Relevance 0.20 Pain Relevance 0.07
In human cornea, multiple groups have reported the expression of TLR3 [14,15], TLR4 [16,17], and TLR5 [18] mRNA and proteins.
Negative_regulation (reported) of Transcription (expression) of TLR4 in cornea
2) Confidence 0.33 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2768757 Disease Relevance 0.33 Pain Relevance 0.07

General Comments

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