INT24644

Context Info Confidence 0.42 First Reported 1980 Last Reported 2010 Negated 9 Speculated 1 Reported most in Body Documents 18 Total Number 19 Disease Relevance 15.44 Pain Relevance 0.91

Anatomy Link Frequency plasma 2 blood 1 fats 1 liver 1 Hdlcl1 (Mus musculus)

Pain Link Frequency Relevance Heat Bile 6 91.76 depression 1 88.56 tolerance 9 84.28 Inflammation 29 81.24 headache 2 79.92 Endocannabinoid 35 75.00 Angina 9 75.00 ischemia 8 75.00 Dismenorea 1 74.36 cva 9 67.32

Disease Link Frequency Relevance Heat Disorder Of Lipid Metabolism 680 100.00 Obesity 191 99.50 Atherosclerosis 131 99.16 Acquired Immune Deficiency Syndrome Or Hiv Infection 52 99.12 Hyperlipidemia 42 99.02 Diabetes Mellitus 260 98.52 Pressure And Volume Under Development 12 97.68 Coronary Artery Disease 91 95.00 Adverse Drug Reaction 1 93.36 Increased Venous Pressure Under Development 131 92.40

Sentences Mentioned In

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Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Slight changes in liver weight, cholesterol, HDL-cholesterol and glucose were observed in male and female animals.

Regulation (changes) of HDL-cholesterol in liver associated with disorder of lipid metabolism

1) Confidence 0.42 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16647233 Disease Relevance 0.37 Pain Relevance 0.13

However, while there was a substantial reduction in triglycerides in the fibrate group at study end, there was essentially no effect on HDL-cholesterol.

Neg (no) Regulation (effect) of HDL-cholesterol associated with disorder of lipid metabolism

2) Confidence 0.38 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 1.02 Pain Relevance 0

Effects on HDL-cholesterol were essentially identical between groups, with additional reductions in LDL-cholesterol and triglycerides arising from statin treatment.

Regulation (Effects) of HDL-cholesterol associated with disorder of lipid metabolism

3) Confidence 0.38 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.50 Pain Relevance 0.05

Low HDL-cholesterol is an independent cardiovascular risk factor

Neg (independent) Regulation (independent) of HDL-cholesterol associated with disorder of lipid metabolism

4) Confidence 0.28 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.94 Pain Relevance 0

Statins remain the mainstay of lipid-modifying therapy according to current guidelines, but exert relatively little effect on HDL-cholesterol, as described above.

Neg (little) Regulation (effect) of HDL-cholesterol associated with disorder of lipid metabolism

5) Confidence 0.28 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.39 Pain Relevance 0

Plasma levels of cholesterol, triglycerides, and LDL- and HDL-cholesterol did not show any significant alterations.

Neg (not) Regulation (alterations) of HDL-cholesterol in Plasma associated with disorder of lipid metabolism

6) Confidence 0.25 Published 1988 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 2468868 Disease Relevance 0.48 Pain Relevance 0.24

The effects of Niaspan® on HDL-cholesterol are essentially identical to those of immediate-release nicotinic acid.

Regulation (effects) of HDL-cholesterol associated with disorder of lipid metabolism

7) Confidence 0.17 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.68 Pain Relevance 0

The mean value of HDL-cholesterol at the end of ARBITER 3 was similar in groups who had previously received placebo or Niaspan® in ARBITER 2 (1.25 mmol/L [48.5 mg/dL] and 1.26 mmol/L [48.6 mg/dL], respectively).

Regulation (value) of HDL-cholesterol associated with disorder of lipid metabolism

8) Confidence 0.17 Published 2007 Journal Vascular Health and Risk Management Section Body Doc Link PMC2291331 Disease Relevance 0.57 Pain Relevance 0

In types IIa, IIb and IV hyperlipoproteinaemia cholesterol, triglycerides, LDL-cholesterol and HDL-cholesterol were affected markedly stronger by procetofene and bezafibrate than by etofibrate retard.

Regulation (affected) of HDL-cholesterol associated with hyperlipidemia and disorder of lipid metabolism

9) Confidence 0.06 Published 1980 Journal Artery Section Abstract Doc Link 7458677 Disease Relevance 0.44 Pain Relevance 0.08

There were no changes in total or VLDL-triglycerides or total HDL-cholesterol.

Neg (no) Regulation (changes) of HDL-cholesterol associated with disorder of lipid metabolism

10) Confidence 0.06 Published 1984 Journal Acta Med. Scand. Suppl. Section Abstract Doc Link 6587755 Disease Relevance 0.57 Pain Relevance 0.15

In conclusion, policosanol administered at 10 mg/day produces more advantageous changes in HDL-cholesterol and has a better safety and tolerability profile than lovastatin 20 mg/day.

Regulation (changes) of HDL-cholesterol associated with disorder of lipid metabolism

11) Confidence 0.03 Published 1999 Journal Int J Clin Pharmacol Res Section Abstract Doc Link 10939029 Disease Relevance 0.86 Pain Relevance 0

The associations of CD4 cell count and HIV-1 viral load were similar for the absolute value of HDL-cholesterol and for total cholesterol.

Regulation (value) of HDL-cholesterol associated with acquired immune deficiency syndrome or hiv infection and disorder of lipid metabolism

12) Confidence 0.01 Published 2008 Journal The Open AIDS Journal Section Body Doc Link PMC2556198 Disease Relevance 1.44 Pain Relevance 0

In comparison with baseline values, no significant change was observed in blood glucose, total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, creatinine, TBARS and TAP in placebo-treated group.

Neg (no) Regulation (change) of HDL-cholesterol in blood associated with disorder of lipid metabolism

13) Confidence 0.01 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2892343 Disease Relevance 1.03 Pain Relevance 0

Anandamide, OEA and PEA correlated positively (p < .05) with SAT leptin mRNA and free fatty acid during hyperinsulinaemic clamp, and negatively with SAT LPL activity and plasma HDL-cholesterol, which were all specifically altered in OBT2D subjects.

Regulation (altered) of HDL-cholesterol in plasma associated with obesity and disorder of lipid metabolism

14) Confidence 0.01 Published 2010 Journal Lipids Health Dis Section Abstract Doc Link PMC2868848 Disease Relevance 1.33 Pain Relevance 0.12

In non diabetic Japanese subjects, Tokunaga et al. [43] found that the -1535T/T genotype modulates lipid levels promoting lower serum triglyceride levels and higher HDL-cholesterol levels.

Regulation (modulates) of HDL-cholesterol associated with diabetes mellitus and disorder of lipid metabolism

15) Confidence 0.01 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2857825 Disease Relevance 1.04 Pain Relevance 0

Metabolic parameters including HbA1C, triglycerides, total cholesterol, HDL-cholesterol and CRP did not change in placebo group during the study.

Neg (not) Regulation (change) of HDL-cholesterol associated with disorder of lipid metabolism

16) Confidence 0.01 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2911454 Disease Relevance 0.53 Pain Relevance 0.04

On the basis of TC:HDL-cholesterol effects alone, 9% of CHD events would be prevented by replacement of TFA in Iranian homes with cis-unsaturated fats (8% by replacement with saturated fats).

Regulation (effects) of HDL-cholesterol in fats associated with disorder of lipid metabolism

17) Confidence 0.00 Published 2010 Journal Nutr J Section Body Doc Link PMC3022640 Disease Relevance 0.77 Pain Relevance 0

These data suggest that a moderate physical training may be sufficient to increase the antioxidative status and decrease the atherosclerotic index but appears to have little further effect on HDL-cholesterol.

Neg (little) Spec (appears) Regulation (effect) of HDL-cholesterol associated with atherosclerosis and disorder of lipid metabolism

18) Confidence 0.00 Published 2007 Journal Nutrition Research and Practice Section Body Doc Link PMC2882571 Disease Relevance 1.01 Pain Relevance 0

In contrast to hormone replacement therapy, raloxifene has no effect on HDL-cholesterol and PAI-1 and a lesser effect on HDL2-cholesterol and lipoprotein (a) (Walsh et al 1998).

Neg (no) Regulation (effect) of HDL-cholesterol associated with disorder of lipid metabolism

19) Confidence 0.00 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544368 Disease Relevance 1.13 Pain Relevance 0.10

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