INT246463

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 6
Disease Relevance 2.73
Pain Relevance 0.75

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
brain 1
pituitary 1
GHS (Homo sapiens)
Pain Link Frequency Relevance Heat
Somatostatin 40 95.52 Very High Very High Very High
medulla 20 94.60 High High
agonist 85 94.52 High High
Dopamine 10 94.00 High High
Inflammation 50 92.08 High High
antagonist 96 84.60 Quite High
Cholecystokinin 5 75.56 Quite High
Cannabinoid 10 70.92 Quite High
vagus nerve 15 59.12 Quite High
tolerance 20 56.40 Quite High
Disease Link Frequency Relevance Heat
Aging 48 99.76 Very High Very High Very High
Growth Problems 25 99.28 Very High Very High Very High
Intellectual Impairment 5 94.80 High High
Sepsis 25 94.32 High High
Birth Weight 5 92.80 High High
INFLAMMATION 60 92.08 High High
Placental Insufficiency 5 92.08 High High
Acute Renal Failure 10 91.52 High High
Cognitive Disorder 7 75.00 Quite High
Fetal Weight 5 73.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dorsal vagal neuronal GHS-R1a levels may decline with aging in the rat [344].
Spec (may) Negative_regulation (decline) of GHS in neuronal associated with aging
1) Confidence 0.17 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.21 Pain Relevance 0.34
In two families, short stature accompanied GHS-R1a mutations that reduced constitutive GHS-R1a activity [27], thereby implying biological relevance of basal receptor activity.
Negative_regulation (reduced) of GHS associated with growth problems
2) Confidence 0.17 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.34 Pain Relevance 0.24
Contrastingly, glucocorticoid deficiency, and glucocorticoid excess alter the GHS axis by, respectively, diminishing blood ghrelin and brain GHS-R1a levels [421, 602, 603].
Negative_regulation (diminishing) of GHS in brain
3) Confidence 0.16 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.89 Pain Relevance 0.12
Postpartum acylghrelin concentrations increase by several-fold over midpregnancy values [613], but GH responses to GHS are reduced in breastfeeding women, especially in the hyperprolactinemic setting [614].
Negative_regulation (reduced) of GHS
4) Confidence 0.14 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.25 Pain Relevance 0
The basis may involve pregnancy-associated suppression of hypothalamic GHRH and GHS-R1a with reciprocal induction of the SS gene due to feedback by high placental somatomammotropin (GH isotype V) and maternal IGF-I concentrations [422].
Negative_regulation (suppression) of GHS
5) Confidence 0.07 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.24 Pain Relevance 0
Several possible mechanisms for the age-related decline in GH secretion have been postulated: loss of (or decline in) pituitary responsiveness to GHS, increased sensitivity to the negative feedback by IGF-I, decline in hypothalamic stimulation, and increase in somatostatin inhibition of GH (Anawalt and Merriam 2001; Merriam and Cummings 2003).
Negative_regulation (responsiveness) of GHS in pituitary associated with somatostatin
6) Confidence 0.06 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.81 Pain Relevance 0.05

General Comments

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