INT246464

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Context Info
Confidence 0.27
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 9
Disease Relevance 4.68
Pain Relevance 0.51

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
body 4
neuronal 2
fat 2
neurons 2
somatotrope 2
GHS (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 80 95.04 Very High Very High Very High
ischemia 16 92.28 High High
cytokine 32 87.08 High High
vagus nerve 24 83.68 Quite High
antagonist 153 83.44 Quite High
cva 9 80.08 Quite High
Somatostatin 61 76.16 Quite High
Arthritis 8 51.60 Quite High
adenocard 8 45.80 Quite Low
agonist 136 40.80 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 136 99.96 Very High Very High Very High
Growth Problems 40 99.50 Very High Very High Very High
Renal Failure 32 96.16 Very High Very High Very High
Aging 57 95.76 Very High Very High Very High
INFLAMMATION 96 95.04 Very High Very High Very High
Disease 11 94.52 High High
Cv Unclassified Under Development 16 92.28 High High
Endotoxemia 8 91.76 High High
Injury 40 91.00 High High
Hyperphagia 8 85.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Conversely, overexpression of neuronal GHS-R1a in female mice elevates GH and GHRH gene expression [28].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GHS in neuronal
1) Confidence 0.27 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.19 Pain Relevance 0.04
Mutational disruption of constitutive GHS-R1a activity is associated with short stature in humans [27], whereas overexpression of GHS-R1a on GHRH neurons augments postweaning growth, reduces fat mass, and augments GHRH and GH gene expression in mice [28].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GHS in neurons associated with growth problems
2) Confidence 0.27 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.17 Pain Relevance 0.07
In a third model, overexpression of GHS-R1a in GHRH neurons increased organ and muscle weight, while decreasing body fat in female animals [28].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GHS in body
3) Confidence 0.27 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.63 Pain Relevance 0
Long-term surveillance of ghrelin and GHS receptor-deficient and ghrelin-overexpressing transgenic animals will be needed to assess whether prolonged changes in ghrelin availability influence immune function or inflammatory disease.

5.11.

Positive_regulation (overexpressing) of Gene_expression (overexpressing) of GHS associated with targeted disruption, inflammation and disease
4) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 1.87 Pain Relevance 0.32
Reduced pituitary action of SS is unlikely to be the sole potentiating mechanism subserving GHS action, since GHS and GHRH synergize even after immunoneutralization of SS [268].
Positive_regulation (since) of Gene_expression (synergize) of GHS in pituitary
5) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.11 Pain Relevance 0.04
In a third model, overexpression of GHS-R1a in GHRH neurons increased organ and muscle weight, while decreasing body fat in female animals [28].
Positive_regulation (overexpression) of Gene_expression (overexpression) of GHS in body
6) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.63 Pain Relevance 0
In addition, prolonged administration of ghrelin or synthetic GHS in humans augments GH, IGF-I and IGFBP-3 concentrations and lean-body mass, and diminishes total-body fat, while eliciting transient secretion of adenocorticotropin hormone (ACTH), cortisol, and prolactin [64, 269–273].
Positive_regulation (augments) of Gene_expression (synthetic) of GHS in fat
7) Confidence 0.19 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2925380 Disease Relevance 0.18 Pain Relevance 0.04
Integrating GHS into the Ghrelin System

Oligopeptide derivatives of metenkephalin were found to stimulate growth-hormone (GH) release directly by pituitary somatotrope cells in vitro in 1977.

Positive_regulation (derivatives) of Gene_expression (Integrating) of GHS in somatotrope
8) Confidence 0.17 Published 2010 Journal International Journal of Peptides Section Title Doc Link PMC2925380 Disease Relevance 0.18 Pain Relevance 0
Stimulating GH with GHS instead of GH replacement has the advantage of a more physiological approach to increase endogenous GH pulsatility with theoretically decreased risk for side effects (Arvat et al 2000).
Positive_regulation (Stimulating) of Gene_expression (replacement) of GHS
9) Confidence 0.07 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544358 Disease Relevance 0.72 Pain Relevance 0

General Comments

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