INT246480

Context Info Confidence 0.14 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 1.45 Pain Relevance 0.03

extracellular region (ALB, SHBG) transport (ALB) small molecule metabolic process (ALB) enzyme binding (ALB) DNA binding (ALB) protein complex (ALB)

ALB (Homo sapiens) SHBG (Homo sapiens)

Pain Link Frequency Relevance Heat depression 6 62.52 transdermal 12 5.00 Inflammation 6 5.00 corticosteroid 5 5.00 Angina 4 5.00 tolerance 4 5.00 cytokine 3 5.00 Opioid 3 5.00 Lasting pain 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Reprotox - General 2 70 92.28 Aging 49 83.60 Virilism 1 69.84 Depression 6 62.52 Reprotox - General 1 52 60.68 Fatigue 6 60.04 Hypogonadotropic Hypogonadism 73 54.76 Syndrome 10 54.04 Injury 5 53.56 Congenital Anomalies 1 40.52

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Testosterone binds strongly to SHBG, and it is therefore largely the free and albumin-bound testosterone that is available for biological action (10).

albumin Binding (binds) of SHBG

1) Confidence 0.14 Published 2010 Journal International Journal of Clinical Practice Section Body Doc Link PMC2948422 Disease Relevance 0.21 Pain Relevance 0

Total serum testosterone consists of free testosterone (2%–3%), testosterone bound to sex hormone binding globulin (SHBG) (45%) and testosterone bound to other proteins (mainly albumin ?

albumin Binding (bound) of SHBG

2) Confidence 0.11 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2544367 Disease Relevance 1.23 Pain Relevance 0.03

General Comments

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