INT246500

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Context Info
Confidence 0.19
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.57
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mtx1)
Mtx1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 6 85.04 High High
methotrexate 1 50.00 Quite Low
rheumatoid arthritis 1 50.00 Quite Low
visual analogue scale 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 34 99.24 Very High Very High Very High
Pain 6 85.04 High High
Disease 6 78.16 Quite High
Toxicity 4 5.00 Very Low Very Low Very Low
INFLAMMATION 2 5.00 Very Low Very Low Very Low
Congenital Anomalies 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Rheumatic Diseases 1 5.00 Very Low Very Low Very Low
Chronic Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This report presents five observations in patients with RA over 25 yrs from 1980 to 2005 at two sites in Finland and Tennessee: (i) weekly, low-dose MTX has replaced intramuscular gold injections as the primary therapy for RA, taken by >90% of the patients; (ii) MTX has been used at progressively shorter intervals after presentation, to the point where it is prescribed within a month of presentation at these sites; (iii) shortening of the interval from diagnosis to initiation of MTX at the US site antedated the Finnish site by about a decade; (iv) these changes have coincided with substantially improved radiographic outcomes in Finland and functional outcomes in Nashville; and (v) the improved outcomes seen in most of these patients antedated availability of biological agents for RA.
Positive_regulation (intervals) of MTX Binding (used) of associated with rheumatoid arthritis
1) Confidence 0.19 Published 2008 Journal Rheumatology (Oxford, England) Section Body Doc Link PMC2544432 Disease Relevance 0.57 Pain Relevance 0.22

General Comments

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