INT246502

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 8.90
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein binding, bridging (Men1) embryo development (Men1) DNA binding (Men1)
protein complex (Men1) cytoplasm (Men1) cytosol (Men1)
Men1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
imagery 15 82.92 Quite High
Serotonin 12 74.60 Quite High
5HT 3 67.92 Quite High
abdominal pain 3 22.56 Low Low
Somatostatin 12 16.44 Low Low
agonist 3 9.80 Low Low
dopamine receptor 3 9.44 Low Low
Dopamine 3 5.12 Low Low
Pain 5 5.00 Very Low Very Low Very Low
depression 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Multiple Endocrine Neoplasia Type 1 237 100.00 Very High Very High Very High
Cancer 154 99.52 Very High Very High Very High
Uterine Fibroids 3 99.36 Very High Very High Very High
Lipoma 3 98.76 Very High Very High Very High
Nasal Tumor 3 97.84 Very High Very High Very High
Carcinoid 70 97.60 Very High Very High Very High
Multiple Endocrine Neoplasia Type 2a 9 94.56 High High
Metastasis 8 90.36 High High
Syndrome 23 89.76 High High
Disease 9 88.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Also in sporadic MEN1-associated tumours mutations of the MEN1 gene have been found, which suggests that inactivation of the MEN1 gene contributes to the development of these tumours.
Negative_regulation (inactivation) of MEN1 associated with multiple endocrine neoplasia type 1 and cancer
1) Confidence 0.30 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.30 Pain Relevance 0.11
In accordance with Knudson's "two-hit theory", biallelic inactivation of the MEN1 gene is required for the development of a tumour cell [12].
Negative_regulation (inactivation) of MEN1 associated with multiple endocrine neoplasia type 1 and cancer
2) Confidence 0.30 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 2.30 Pain Relevance 0.22
The prevalence of MEN1 is 2-3 per 100,000, and is equal among males and females.
Negative_regulation (prevalence) of MEN1 associated with multiple endocrine neoplasia type 1
3) Confidence 0.26 Published 2005 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2837063 Disease Relevance 1.99 Pain Relevance 0
It should be mentioned that carcinoid is not infrequently associated with MEN1 and loss of 11q, sometimes independently of the MEN1 gene (11q13), suggesting loss of MEN1 or another tumour suppressor gene is responsible for the condition.
Negative_regulation (loss) of MEN1 associated with multiple endocrine neoplasia type 1, carcinoid and cancer
4) Confidence 0.20 Published 2008 Journal Cases J Section Body Doc Link PMC2546371 Disease Relevance 2.30 Pain Relevance 0

General Comments

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