INT24651

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Context Info
Confidence 0.47
First Reported 1989
Last Reported 2003
Negated 0
Speculated 1
Reported most in Abstract
Documents 12
Total Number 13
Disease Relevance 2.88
Pain Relevance 8.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cofactor metabolic process (Ppt1) Golgi apparatus (Ppt1) cytosol (Ppt1)
extracellular space (Ppt1) protein modification process (Ppt1) extracellular region (Ppt1)
Anatomy Link Frequency
dorsal root ganglia 8
striatum 6
neurons 4
lungs 2
midbrain 1
Ppt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 17 100.00 Very High Very High Very High
Dorsal horn 10 100.00 Very High Very High Very High
substance P 72 99.72 Very High Very High Very High
qutenza 9 99.72 Very High Very High Very High
Sciatic nerve 3 99.16 Very High Very High Very High
Nerve growth factor 7 98.04 Very High Very High Very High
Neuropeptide 7 97.40 Very High Very High Very High
spinal dorsal horn 1 97.04 Very High Very High Very High
agonist 5 96.32 Very High Very High Very High
Dynorphin 10 96.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 12 99.92 Very High Very High Very High
Bronchitis 3 98.74 Very High Very High Very High
Pain 5 95.56 Very High Very High Very High
INFLAMMATION 15 94.36 High High
Arthritis 5 91.80 High High
Syndrome 1 90.00 High High
Experimental Arthritis 2 79.96 Quite High
Hyperalgesia 3 5.00 Very Low Very Low Very Low
Arthropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of these studies was to determine if substance P (SP) content in the trachea or lungs was elevated in this animal model of chronic bronchitis, and whether an increase in SP content was associated with an increase in preprotachykinin gene-I (PPT) mRNA expression.
Spec (whether) Positive_regulation (increase) of Transcription (expression) of PPT in lungs associated with bronchitis and substance p
1) Confidence 0.47 Published 1996 Journal Am. J. Respir. Cell Mol. Biol. Section Abstract Doc Link 8600937 Disease Relevance 0.36 Pain Relevance 0.38
Following injection of adjuvant into the bilateral hind paws, the levels of PPT-A mRNA were significantly increased in the dorsal root ganglia at L4-L6 levels and the lumbar spinal cord, but not in the striatum, midbrain and medulla oblongata.
Positive_regulation (increased) of Transcription (levels) of PPT in striatum associated with medulla, midbrain and spinal cord
2) Confidence 0.45 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2469044 Disease Relevance 0.33 Pain Relevance 0.69
Striatal preprotachykinin (PPT) mRNA levels were significantly increased 8 days following injection.
Positive_regulation (increased) of Transcription (levels) of PPT
3) Confidence 0.42 Published 1997 Journal Dev. Neurosci. Section Abstract Doc Link 9097028 Disease Relevance 0 Pain Relevance 0.40
The increased peptide levels were associated with increases in the abundance of PD mRNA and PPT mRNA and increases in the rate of transcription of PD and PPT genes in the striatum, suggesting a GBR-induced activation of the striatonigral tachykinin and dynorphin neurons.
Positive_regulation (increases) of Transcription (abundance) of PPT in neurons associated with dynorphin
4) Confidence 0.39 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.67
IL-1beta increases SP synthesis by enhancing the expression of preprotachykinin (PPT) mRNA encoding for SP and other tachykinins in the DRG.
Positive_regulation (enhancing) of Transcription (expression) of PPT in DRG associated with substance p
5) Confidence 0.34 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622206 Disease Relevance 0.10 Pain Relevance 0.41
Only apomorphine and quinpirole increased the abundance of PPT mRNA in the intact striatum.
Positive_regulation (increased) of Transcription (abundance) of PPT in striatum
6) Confidence 0.31 Published 1996 Journal J Neural Transm Section Abstract Doc Link 8739837 Disease Relevance 0 Pain Relevance 0.46
Following injection of either formalin or complete Freund's adjuvant (CFA) into one hindpaw, the levels of expression of NK-1 and NK-3 mRNAs in the spinal cord dorsal horn and preprotachykinin (PPT) mRNA expression in the lumbar dorsal root ganglia (DRG) were quantitated using solution hybridization-nuclease protection assays.
Positive_regulation (levels) of Transcription (expression) of PPT in dorsal root ganglia associated with dorsal horn and spinal cord
7) Confidence 0.30 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.33 Pain Relevance 0.72
Following injection of either formalin or complete Freund's adjuvant (CFA) into one hindpaw, the levels of expression of NK-1 and NK-3 mRNAs in the spinal cord dorsal horn and preprotachykinin (PPT) mRNA expression in the lumbar dorsal root ganglia (DRG) were quantitated using solution hybridization-nuclease protection assays.
Positive_regulation (Following) of Transcription (expression) of PPT in dorsal root ganglia associated with dorsal horn and spinal cord
8) Confidence 0.30 Published 1994 Journal J. Neurosci. Section Abstract Doc Link 8301359 Disease Relevance 0.34 Pain Relevance 0.74
The increased peptide levels were associated with increases in the abundance of PD mRNA and PPT mRNA and increases in the rate of transcription of PD and PPT genes in the striatum, suggesting a GBR-induced activation of the striatonigral tachykinin and dynorphin neurons.
Positive_regulation (increases) of Transcription (transcription) of PPT in neurons associated with dynorphin
9) Confidence 0.28 Published 1996 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 8717356 Disease Relevance 0 Pain Relevance 0.68
In contrast, gamma-PPT mRNA and trkA mRNA expression in DRG were significantly increased after capsaicin treatment.
Positive_regulation (increased) of Transcription (expression) of PPT in DRG associated with qutenza
10) Confidence 0.22 Published 1997 Journal Neurosci. Lett. Section Abstract Doc Link 9259450 Disease Relevance 0.79 Pain Relevance 1.57
CORT replacement resulted in recovered PPE and PPT mRNA levels after 1 day and elevated PPE mRNA levels over those in sham-operated controls after 3 days.
Positive_regulation (resulted) of Transcription (levels) of PPT
11) Confidence 0.20 Published 1998 Journal J. Neurochem. Section Abstract Doc Link 9681476 Disease Relevance 0 Pain Relevance 0.33
Following injection of adjuvant into the bilateral hind paws, the levels of PPT-A mRNA were significantly increased in the dorsal root ganglia at L4-L6 levels and the lumbar spinal cord, but not in the striatum, midbrain and medulla oblongata.
Positive_regulation (increased) of in midbrain Transcription (levels) of PPT in striatum associated with medulla, midbrain and spinal cord
12) Confidence 0.15 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2469044 Disease Relevance 0.33 Pain Relevance 0.69
Following injection of adjuvant into the bilateral hind paws, the levels of PPT-A mRNA were significantly increased in the dorsal root ganglia at L4-L6 levels and the lumbar spinal cord, but not in the striatum, midbrain and medulla oblongata.
Positive_regulation (increased) of in medulla oblongata Transcription (levels) of PPT in striatum associated with medulla, midbrain and spinal cord
13) Confidence 0.15 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2469044 Disease Relevance 0.33 Pain Relevance 0.69

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