INT246514

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Context Info
Confidence 0.51
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.98
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (NAMPT) signal transduction (NAMPT) small molecule metabolic process (NAMPT)
transferase activity, transferring glycosyl groups (NAMPT) cell-cell signaling (NAMPT) cytoplasm (NAMPT)
NAMPT (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 30 91.08 High High
methadone 14 70.60 Quite High
iatrogenic 1 64.84 Quite High
addiction 22 55.64 Quite High
fibrosis 2 32.72 Quite Low
Inflammatory response 7 5.00 Very Low Very Low Very Low
anesthesia 6 5.00 Very Low Very Low Very Low
cytokine 5 5.00 Very Low Very Low Very Low
Angina 4 5.00 Very Low Very Low Very Low
Buprenorphine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 208 98.52 Very High Very High Very High
Cancer 8 98.20 Very High Very High Very High
Apoptosis 6 96.44 Very High Very High Very High
Disease 14 96.12 Very High Very High Very High
Sepsis 10 95.84 Very High Very High Very High
Esophageal Cancer 13 93.52 High High
Disorders Of Creatine Metabolism 2 93.48 High High
INFLAMMATION 33 91.08 High High
Anastomotic Leak 9 86.08 High High
Aspiration Pneumonia 1 84.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An inhibitor of visfatin (FK866) is being tested as a potential anti-tumor agent due to NAD depletion leading to apoptosis on highly metabolically active cells [19].
Negative_regulation (inhibitor) of visfatin associated with cancer and apoptosis
1) Confidence 0.51 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2857825 Disease Relevance 0.89 Pain Relevance 0.09
Four patients (#11, 13, 16, 20) received long-term sivelestat and displayed significant downregulation of NAMPT and MUC1 mRNA (p < 0.001 and 0.034 by one-way ANOVA) compared with the 23 patients who did not receive this medication.
Negative_regulation (downregulation) of NAMPT
2) Confidence 0.44 Published 2010 Journal J Transl Med Section Body Doc Link PMC2984412 Disease Relevance 0.89 Pain Relevance 0.12
Visfatin is also diminished in patients with steatohepatitis when compared to pure steatosis [16].
Negative_regulation (diminished) of Visfatin
3) Confidence 0.44 Published 2010 Journal Diabetol Metab Syndr Section Body Doc Link PMC2857825 Disease Relevance 0.66 Pain Relevance 0.09
Challenges remain for WHO, working with advocacy partners, to expand the supportive political environment for harm reduction in Viet Nam and in the development of effective HIV prevention and care linkages between closed settings ('Treatment and Education' centres/prisons) and communities.


Negative_regulation (reduction) of Nam associated with acquired immune deficiency syndrome or hiv infection
4) Confidence 0.00 Published 2008 Journal Harm Reduct J Section Body Doc Link PMC2546385 Disease Relevance 0.55 Pain Relevance 0.07

General Comments

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