INT246520

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2008
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 2.54
Pain Relevance 0.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
myocyte 2
Tnnc1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 56 98.90 Very High Very High Very High
cytokine 4 58.24 Quite High
ischemia 20 5.00 Very Low Very Low Very Low
Inflammatory response 12 5.00 Very Low Very Low Very Low
isoflurane 8 5.00 Very Low Very Low Very Low
methadone 4 5.00 Very Low Very Low Very Low
Opioid 4 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 60 98.90 Very High Very High Very High
Systemic Inflammatory Response Syndrome 136 98.58 Very High Very High Very High
Heart Disease 8 98.16 Very High Very High Very High
Pyometra 136 95.64 Very High Very High Very High
Hypoxia 4 93.20 High High
Injury 20 92.56 High High
Toxicity 4 92.24 High High
Ischemic Heart Disease 16 86.04 High High
Death 8 83.92 Quite High
Myocardial Infarction 4 51.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Further studies are needed to investigate whether increased concentrations of cTnI are associated with a higher risk of perioperative complications.


Spec (whether) Positive_regulation (increased) of Spec (whether) Positive_regulation (concentrations) of cTnI
1) Confidence 0.49 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.46 Pain Relevance 0.07
A possible cause for the increased cTnI concentrations could be the presence of endotoxins into the circulation.
Spec (possible) Positive_regulation (cause) of Positive_regulation (increased) of cTnI
2) Confidence 0.45 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.63 Pain Relevance 0.06
Ongoing myocyte damage because of SIRS or inflammation induced by systemically released endotoxin could also contribute to elevated concentrations of cTnI postsurgically.
Positive_regulation (contribute) of Positive_regulation (elevated) of cTnI in myocyte associated with inflammation and systemic inflammatory response syndrome
3) Confidence 0.45 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.73 Pain Relevance 0.09
Two of the healthy control dogs in our study (which all had undetectable concentrations of cTnI preoperatively) had increased concentrations of cTnI after surgery.
Positive_regulation (increased) of Positive_regulation (concentrations) of cTnI
4) Confidence 0.43 Published 2008 Journal Acta Vet Scand Section Body Doc Link PMC2546406 Disease Relevance 0.71 Pain Relevance 0.11

General Comments

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