INT246620

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Context Info
Confidence 0.39
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.90
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Sirt1) nucleoplasm (Sirt1) nuclear envelope (Sirt1)
histone binding (Sirt1) enzyme binding (Sirt1) cytoplasm (Sirt1)
Sirt1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 95 98.44 Very High Very High Very High
Hippocampus 6 74.16 Quite High
cytokine 13 49.36 Quite Low
cINOD 16 5.00 Very Low Very Low Very Low
Nicotine 13 5.00 Very Low Very Low Very Low
Inflammatory response 9 5.00 Very Low Very Low Very Low
Somatostatin 9 5.00 Very Low Very Low Very Low
agonist 8 5.00 Very Low Very Low Very Low
diclofenac 4 5.00 Very Low Very Low Very Low
ischemia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 106 98.44 Very High Very High Very High
Aging 11 92.44 High High
Alzheimer's Dementia 11 92.00 High High
Toxicity 4 91.36 High High
Neurodegenerative Disease 6 89.44 High High
Disease 144 88.56 High High
Drug Induced Neurotoxicity 4 88.16 High High
Neurological Disease 3 86.76 High High
Pathologic Processes 1 82.08 Quite High
Cancer 15 70.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Chen and co-workers (2005) showed that by activating SIRT-1, resveratrol inhibited, indirectly, nuclear factor ?
Negative_regulation (inhibited) of Positive_regulation (activating) of SIRT-1
1) Confidence 0.39 Published 2008 Journal Clinical Interventions in Aging Section Body Doc Link PMC2546476 Disease Relevance 1.12 Pain Relevance 0.04
Resveratrol has anti-inflammatory properties due to its activation of SIRT-1, a class III histone deacetylase; activation of SIRT-1 by resveratrol inhibited NF-?
Negative_regulation (inhibited) of Positive_regulation (activation) of SIRT-1 associated with inflammation
2) Confidence 0.09 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.78 Pain Relevance 0.13

General Comments

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